Medical research

Team finds molecule that triggers septic shock

The body's immune system is set up much like a home security system; it has sensors on the outside of cells that act like motion detectors—floodlights—that click on when there's an intruder rustling in the bushes, bacteria ...

Oncology & Cancer

New inhibitor blocks the oncogenic protein KRAS

One of the major goals in the development of anti-cancer treatments is to find an inhibitor effective against the oncogenic protein known as KRAS. Despite decades of active agent research, efforts to intercede in this protein's ...

Medical research

The flexible tail of the prion protein poisons brain cells

For decades, there has been no answer to the question of why the altered prion protein is poisonous to brain cells. Neuropathologists from the University of Zurich and University Hospital Zurich have now shown that it is ...

Medical research

Scientists find 3D structure of key drug target for diabetes

An international team led by scientists at The Scripps Research Institute (TSRI) has determined and analyzed the three-dimensional atomic structure of the human glucagon receptor. The receptor, found mainly on liver and kidney ...

Oncology & Cancer

Researchers identify potential biomarker for cancer diagnosis

Scientists studying cancer development have known about micronuclei for some time. These erratic, small extra nuclei, which contain fragments, or whole chromosomes that were not incorporated into daughter cells after cell ...

Medical research

Researchers design variant of main painkiller receptor

Opioids, such as morphine, are still the most effective class of painkillers, but they come with unwanted side effects and can also be addictive and deadly at high doses. Designing new pain-killing drugs of this type involves ...

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