Neuroscience

Scientists create new map of brain's immune system

A team of researchers under the direction of the Medical Center—University of Freiburg has created an entirely new map of the brain's own immune system in humans and mice. The scientists demonstrated for the first time ...

Neuroscience

Faulty molecular master switch may contribute to AMD

A signaling pathway controlled by transforming growth factor beta (TGF-beta) could be involved in the progression of age-related macular degeneration (AMD). Researchers at the National Eye Institute (NEI), part of the National ...

Neuroscience

A new hope in treating neurodegenerative disease

Korean researchers have identified the inhibition of autophagy in microglia, brain immune cells. It is expected to help develop treatments for Alzheimer's disease which occur due to the inhibition of autophagy.

Alzheimer's disease & dementia

Immune cell defect stimulates Alzheimer's

Defects in the gene TREM2 are linked to increased risk of Alzheimer's disease. The gene is required to activate immune cells called microglia in the brain, which help to eliminate the neurotoxic deposits that are typical ...

Neuroscience

Microglia transmit pain to the brain during stress

Research in male mice published in JNeurosci demonstrates activation of microglia in the spinal cord is responsible for increased pain sensitivity in response to stress.

Genetics

How glial cells develop in the brain from neural precursor cells

Two types of cells are active in the brain: nerve cells and glial cells. Glial cells have long been regarded primarily as supportive cells, but researchers increasingly recognize that they play an active role in the communication ...

Neuroscience

Classifying brain microglia: Which are good and which are bad?

Microglia are known to be important to brain function. The immune cells have been found to protect the brain from injury and infection and are critical during brain development, helping circuits wire properly. They also seem ...

Oncology & Cancer

Microglia react distinctively during inflammation

The NorLux Neuro-Oncology Laboratory at LIH's Department of Oncology conducts research on brain diseases, with a special emphasis on glioma biology, drug resistance and systems approaches. Within this research unit, Dr. Alessandro ...

Medical research

Researchers hope to be able to replace dysfunctional brain cells

A new study by researchers at Karolinska Institutet supports the theory that replacement of dysfunctional immune cells in the brain has therapeutic potential for neurodegenerative diseases like ALS and Alzheimer's disease. ...

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