Neuroscience

Uncovering how immune cells nurture brain connections

Microglia, the immune cells of the brain, are known for eating up unwanted items like germs and debris, much as their counterparts do in the rest of the body. In early childhood, certain microglia remove unneeded connections, ...

Medications

How long-term benzodiazepine use leads to cognitive impairments

Benzodiazepines are effective and widely used drugs for treating states of anxiety and sleep disorders. While short-term treatments are considered safe, their long-term intake can lead to physical dependence and, particularly ...

Genetics

Can a human microglial atlas guide brain disorder research?

Certain subtle differences in DNA sequences are known to raise the chances a person may develop Alzheimer's or Parkinson's disease. Some of these differences may work by altering the genetic activity of microglia, the brain's ...

Neuroscience

Research clears up how brain 'cleaners' fail in ALS

In preclinical studies, Mayo Clinic scientists and collaborators have identified the molecular mechanism used by the brain's "cleaners" as they remove a problematic protein in the brain. This work, published in Nature Neuroscience, ...

Neuroscience

Study reveals journey of immune cells in developing zebrafish

Microglia, the immune cells of the brain, form the first line of defense against neurodegenerative diseases and traumatic brain injuries. They maintain brain homeostasis, the stable condition necessary for survival, by acting ...

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