Huntington disease is a devastating neurogenerative disorder that causes a progressive loss of functional capacity and reduced life span. It is an inherited condition caused by a mutant HTT gene. Although this has been known ...
Oct 10, 2011
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A team led by Brazilian researcher Elis Eleutherio, professor at the Federal University of Rio de Janeiro, in partnership with Tiago Outeiro, at University of Goettingen, Germany, made important progress in understanding ...
Dec 2, 2019
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Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington's disease have a distinctive structure, a finding that could shed ...
Feb 3, 2016
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In Parkinson's disease, the protein "alpha-synuclein" aggregates within neurons of patients and appears to propagate across interconnected areas of the brain. How this happens remains largely unknown. It has been proposed ...
Jan 5, 2016
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Hypertrophic cardiomyopathy (HCM), a disease in which cardiac muscle thickens, weakening the heart, can be prevented from developing for several months in mice by reducing production of a mutant protein, according to a new ...
Oct 3, 2013
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By using a model, researchers at the University of Montreal have identified and "switched off" a chemical chain that causes neurodegenerative diseases such as Huntington's disease, amyotrophic lateral sclerosis and dementia. ...
Nov 27, 2012
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Circadian rhythms, the internal biological clocks that regulate our daily activities, are essential for maintaining health and well-being. While the role of transcription in these rhythms is well-established, a new study ...
Oct 2, 2023
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A previously invincible mutation in chronic myeloid leukemia (CML) has been thwarted by an investigational drug in a phase I clinical trial reported in the current edition of The New England Journal of Medicine.
Nov 28, 2012
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Scientists at the University of York have discovered the driving force behind the development of prostate cancer.
Mar 27, 2013
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A substantial proportion of NK/T-cell lymphomas harbor Janus Kinase 3 gene mutations. Patients with these lymphomas might benefit from treatment with a Janus Kinase inhibitor according to a study published in Cancer Discovery, ...
Jun 15, 2012
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