Researchers at the University of California San Diego have uncovered a connection between the topography of the human genome and the presence of mutations in human cancer. They found that certain regions of the genome, which ...
Aug 24, 2023
0
25
The first comprehensive study of somatic mutations in normal human small intestine has been conducted by researchers at the Wellcome Sanger Institute and their collaborators. The findings revealed that an enzyme named APOBEC1 ...
Jan 27, 2023
0
21
Researchers at the University of California San Diego have for the first time discovered a pattern of DNA mutations that links bladder cancer to tobacco smoking. The discovery was made possible thanks to a powerful new machine ...
Sep 26, 2022
0
50
A team of researchers affiliated with several institutions in the U.S. and the U.K. has found a link between the APOBEC3A enzyme and the most prevalent mutational signatures in cancer cell lines. In their paper published ...
New research from a collaborative team at Cleveland Clinic, led by Timothy Chan, MD, Ph.D., Chair of the Center for Immunotherapy and Precision Immuno-Oncology in the Lerner Research Institute, is demonstrating that pathogenic ...
Jul 13, 2022
0
53
As an approach to personalized medicine, a new Nature Communications study proposes that "mutational footprints" of DNA repair are a promising predictive genetic marker for determining which tumors will respond to certain ...
May 26, 2022
0
76
DNA analysis of thousands of tumors from NHS patients has found a 'treasure trove' of clues about the causes of cancer, with genetic mutations providing a personal history of the damage and repair processes each patient has ...
Apr 21, 2022
0
176
A genomic analysis of lung cancer in people with no history of smoking has found that a majority of these tumors arise from the accumulation of mutations caused by natural processes in the body. This study was conducted by ...
Sep 6, 2021
0
265
Scientists can use genetic 'weather forecasting' to predict how long it will take for bowel cancer to evolve resistance to a drug before a patient has even started treatment, a new study has shown.
May 21, 2021
0
24
The hidden world of genetic changes, or mutations, in healthy colon tissue has been uncovered by scientists at the Wellcome Sanger Institute and their collaborators. The team developed technology to sequence the genomes of ...
Oct 23, 2019
0
28
