Oncology & Cancer

Breast cancer patients could benefit from controversial hormone

An international team of researchers involving the University of Adelaide is tackling the controversy over what some scientists consider to be a "harmful" hormone, arguing that it could be a game changer in the fight against ...

Oncology & Cancer

Treating breast cancer with progesterone could aid survival

A special technique where breast cancer cells are "rescued" for research has been developed at the University of Adelaide. Coupled with advanced scientific technologies pioneered by Cambridge University this has provided ...

Oncology & Cancer

The switch that might tame the most aggressive of breast cancers

Australian researchers have found that so-called 'triple-negative breast cancers' are two distinct diseases that likely originate from different cell types. This helps explain why survival prospects for women with the diagnosis ...

Oncology & Cancer

New anti-cancer compound shows promise for breast cancer

Melbourne researchers have discovered that anti-cancer compounds currently in clinical trials for some types of leukaemia could offer hope for treating the most common type of breast cancer.

Oncology & Cancer

Discovery opens door for breast, prostate cancer treatments

(Medical Xpress)—A team of Western Australian cancer researchers interested in the strong link between hormones and cancer have discovered three new molecules that may have an important role to play in future breast and ...

Other

Israeli sperm bank posts diminishing returns

Wall Street giants are not the only banks hit by diminishing assets. New research for an Israeli sperm bank shows that depositors are 40 per cent less fertile than a decade ago, the Haaretz daily reported.

Medical research

Grapefruit diet almost cost woman her leg

A woman who ate a grapefruit each day almost had to have her leg amputated because of a dangerous blood clot, according to an unusual case study reported in the Lancet.

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Estrogen

Estrogens (AmE), oestrogens (BE), or œstrogens, are a group of compounds named for their importance in the estrous cycle of humans and other animals. They are the primary female sex hormones. Natural estrogens are steroid hormones, while some synthetic ones are non-steroidal. Their name comes from the Greek words estrus/οίστρος = sexual desire + gen/γόνο = to generate.

Estrogens are synthesized in all vertebrates as well as some insects. Their presence in both vertebrates and insects suggests that estrogenic sex hormones have an ancient evolutionary history.

Estrogens are used as part of some oral contraceptives, in estrogen replacement therapy for postmenopausal women, and in hormone replacement therapy for trans women.

Like all steroid hormones, estrogens readily diffuse across the cell membrane. Once inside the cell, they bind to and activate estrogen receptors which in turn modulate the expression of many genes. Additionally, estrogens have been shown to activate a G protein-coupled receptor, GPR30.

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