Medical research

'Cellular memory' of DNA damage in oocyte quality control

Females are born with a finite number of eggs that are steadily depleted throughout their lifetime. This reserve of eggs is selected from a much larger pool of millions of precursor cells, or oocytes, that form during fetal ...

Medical research

Obesity, infertility and oxidative stress in mouse egg cells

Excessive body fat is associated with negative effects on female fertility and pregnancy. In mice, maternal obesity impairs proper development of egg precursor cells called oocytes. In a recent paper published in Molecular ...

Genetics

Why does making new egg cells require so much cell death?

A highly detailed study of how the roundworm C. elegans forms oocytes suggests that the egg-making process leads to the formation and subsequent destruction of cells with an extra nucleus, but that some cellular materials ...

Obstetrics & gynaecology

Preconception zinc deficiency could spell bad news for fertility

An estimated 10 percent of couples in the U.S. struggle with infertility. While a variety of factors can make it difficult for some people to get pregnant, ovulation disorders are a leading cause of female infertility. Now, ...

Oncology & Cancer

Preserving fertility during chemotherapy

Many chemotherapeutics act by damaging the DNA. Since cancer cells divide more often than most normal cells, they are more sensitive to DNA-damaging agents. One exception are oocytes. To prevent birth defects, they initiate ...

Obstetrics & gynaecology

Demand for fertility preservation increasing for women

(HealthDay)—The demand for fertility preservation is increasing, and methods to address it include oocyte cryopreservation and ovarian-tissue cryopreservation, according to a review article published online Oct. 25 in the ...

Obstetrics & gynaecology

The more eggs the better in IVF?

A higher number of eggs retrieved in an IVF treatment cycle is independently associated with more chromosomally normal embryos available for transfer, according to a new Australian study. However, the benefit of a greater ...

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Oocyte

An oocyte, ovocyte, or rarely ocyte, is a female gametocyte or germ cell involved in reproduction. In other words, it is an immature ovum, or egg cell. An oocyte is produced in the ovary during female gametogenesis. The female germ cells produce a primordial germ cell (PGC) which undergoes a mitotic division to form an oogonium. During oogenesis the oogonium becomes a primary oocyte (pronounced oh'a-site).

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