Diseases, Conditions, Syndromes

Proteasome inhibitors show promise for drug-resistant malaria

Proteasome inhibitors have significant promise as components of novel combination therapies to treat multidrug-resistant malaria, according to a study published June 6 in the open-access journal PLOS Pathogens by David Fidock, ...

Oncology & Cancer

Drug-resistant cancer cells create own Achilles heel

The cells of most patients' cancers are resistant to a class of drugs, called proteasome inhibitors, that should kill them. When studied in the lab, these drugs are highly effective, yet hundreds of clinical trials testing ...

Oncology & Cancer

Addition of elotuzumab ups PFS in refractory multiple myeloma

(HealthDay)—For patients with multiple myeloma in whom treatment with lenalidomide and a proteasome inhibitor has failed, progression-free survival (PFS) is longer in those receiving the immunostimulatory monoclonal antibody ...

Oncology & Cancer

A rare disease inspires a new way to attack cancer

Some of the most promising new treatments for blood cancers, drugs called proteasome inhibitors, have a problem: For reasons that researchers are still working to fully understand, cancer cells can build up a resistance to ...

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