Cold activates a cellular cleansing mechanism that breaks down harmful protein aggregations responsible for various diseases associated with aging. In recent years, studies on different model organisms have already shown ...
Apr 3, 2023
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344
When Yoni Silverman, now 13, was a toddler, his parents fretted as he missed milestone after milestone. The New York City couple took their son to a host of specialists, searching for answers about why he wasn't speaking ...
Mar 16, 2023
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4
Multiple myeloma is a type of cancer that affects plasma cells, the blood cells involved in the production of antibodies. It is the second most common hematologic cancer, accounting for 2% of all cancers of hematologic origin.
Nov 9, 2022
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"How many people actually have this disease?"
Feb 28, 2022
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Multiple myeloma is a cancer of the bone marrow, with a life expectancy of less than 5 years post-diagnosis. Proteasome inhibitors, the therapeutic backbone of current treatments, are very effective in treating newly diagnosed ...
Jan 12, 2022
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18
Managing the waste that cells produce is an essential function of the human body, as any defect in its elimination mechanisms can lead to cancer and neurodegenerative diseases. Now a Canadian study sheds light on a new mechanism ...
Nov 30, 2021
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A drug that strips cancer cells of their quest for immortality represents an effective new option for patients with Waldenström macroglobulinemia, including those not helped by the only class of drugs currently approved ...
Nov 19, 2021
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Cytosolic peptide:N-glycanase (NGLY1) is a widely conserved enzyme involved in de–N-glycosylation of N-glycosylated proteins. Mutations in the human NGLY1 gene cause global developmental delay and multisystemic symptoms, ...
Jul 6, 2021
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5
Misfolding and aggregation of normally soluble proteins are common pathological features of many neurodegenerative diseases, including Alzheimer's, Parkinson's, Creutzfeldt-Jacob and Huntington's diseases. For example, Parkinson's ...
Sep 29, 2020
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5
The aberrant buildup of misfolded proteins is a hallmark of a host of disorders, including neurodegenerative diseases such as Alzheimer's and Parkinson's. Aggregates of these toxic proteins wreak havoc on the function of ...
Jul 22, 2020
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