Cancer gene dependency maps help reveal proteins' relationships
By merging cancer functional genetic data with information on protein interactions, scientists can explore protein complexes at massive scale.
May 17, 2018
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By merging cancer functional genetic data with information on protein interactions, scientists can explore protein complexes at massive scale.
May 17, 2018
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A given gene may perform a different function in breast cancer cells than in healthy cells due to changes in networks of interacting proteins, according to a new study published in PLOS Computational Biology.
Nov 30, 2017
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(Medical Xpress)—A team of researchers with pharmaceutical company Amgen Inc. report that an engineered version of a protein naturally found in the body caused test mice, rats and cynomolgus monkeys to lose weight. In their ...
Researchers at Mayo Clinic have identified an interaction among proteins that allows cancer cells to grow and metastasize. They say the discovery may play a role in developing a better understanding of how tumors grow in ...
Mar 28, 2017
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An in-depth computational analysis of genetic variants implicated in both schizophrenia and rheumatoid arthritis by researchers at the University of Pittsburgh points to eight genes that may explain why susceptibility to ...
Feb 24, 2017
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Nicotinic acetylcholine receptors (nAChRs) have been pursued for decades as potential molecular targets to treat cognitive dysfunction in Alzheimer's disease (AD) due to their demonstrated role in processes underlying cognition ...
Jun 17, 2016
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Lymphatic Filariasis is a neglected tropical disease caused by three different species of parasitic worm, which are spread between human hosts by mosquitos. The molecular interactions between the worm, mosquito and human ...
Sep 24, 2015
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Like the shape-shifting robots of "Transformers" fame, a unique class of proteins in the human body also has the ability to alter their configuration. These so-named intrinsically disordered proteins (IDPs) lack a fixed or ...
Feb 25, 2015
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Researchers in the United States have identified a molecular network that comprises many of the genes previously shown to contribute to autism spectrum disorders. The findings provide a map of some of the crucial protein ...
Dec 30, 2014
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For decades, researchers have struggled to translate basic scientific discoveries about cancer into therapeutics that effectively—and with minimal side effects—shrink a tumor.
Nov 20, 2014
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