Working with mice, Johns Hopkins researchers report they have found previously known skin itch receptors in the airways that appear to contribute to bronchoconstriction and airway hypersensitivity, hallmarks of asthma and ...
Mar 9, 2018
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41
A newly identified protein can be manipulated to make opioid painkillers effective at lower doses while also muting the reward mechanism that leads to addiction, Mount Sinai researchers have found.
Feb 12, 2018
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In recent years, a powerful suite of drugs known as kinase inhibitors have been developed to treat cancer and other diseases. Primary targets of such drugs include a family of receptor tyrosine kinases (RTKs) which protrude ...
Feb 5, 2018
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432
Named after the Greek goddess who spun the thread of life, Klotho proteins play an important role in the regulation of longevity and metabolism. In a recent Yale-led study, researchers revealed the three-dimensional structure ...
Jan 17, 2018
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441
In most cases, prostate cancer is cured by surgery and/or radiotherapy. However, 20 percent of patients will need treatment to remove tumour cells but this treatment ceases to be effective after two or three years and the ...
Dec 13, 2017
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2
Affecting as many as 650 million people worldwide, obesity has become one of the most serious global health issues. Among its detrimental effects, it increases the risk of developing metabolic conditions, and primarily type ...
Nov 28, 2017
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609
An especially aggressive breast cancer cell can respond to hormone therapy if they express a specific protein known as estrogen receptor beta (ERĪ²), according to new research published on the cover of Oncotarget. The findings ...
Nov 15, 2017
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Leptin is an adipocyte-derived hormone that stimulates hypothalamic neurons to strongly inhibit food intake. Leptin signaling in the hypothalamus, a part of the mid-brain, thus plays a crucial role in the regulation of body ...
Sep 15, 2017
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3
The dynamics among certain so-called G protein-coupled receptors, of vital importance for the function of cells in the body, are different than previously believed. This has been reported by researchers from Karolinska Institutet ...
Aug 10, 2017
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Proteins must be in the right place at the right time in the cell to function correctly. This is even more critical in a neuron than in other cells because of its complex tree-like structure and its function. Researchers ...
Jul 19, 2017
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