Immunology

How dendritic cells activate the immune system

The specific or acquired immune system of vertebrates is a powerful weapon against pathogens and pathologically altered body cells. Here, T cells play a special role. After activation, they can systematically kill off target ...

Medical research

When macrophage digestion goes wrong

The exchange of gases between the air we breathe and our blood takes place via alveoli—tiny air sacs in our lungs. For this process to run smoothly, the epithelial cells of the alveoli produce a substance called "surfactant" ...

Medical research

Inflammation triggers fatal cycle in Alzheimer's disease

An immune reaction in the brain seems to play a major role in the development of Alzheimer's disease. In a way, it "adds fuel to the fire" and apparently causes an inflammation that, in a sense, keeps kindling itself. The ...

Immunology

Observing inflammatory cells in the body

The process of inflammation is complex. The main role is played by immune cells migrating from the blood into the tissue to fight the inflammation. If too many of these cells are active, however, they can just as easily cause ...

Immunology

Second 'don't eat me' signal found on cancer cells

A second biological pathway that signals immune cells not to engulf and kill cancer cells has been identified by researchers at the Stanford University School of Medicine.

Neuroscience

Brain defense cells live longer than expected

Eliminating pathogens and cellular waste is an important task of microglia, the immune cells of the brain. They are among the group of non-neural brain cells that support the normal function of nerve cells. A new study now ...

Alzheimer's disease & dementia

Overactive scavenger cells may cause neurodegeneration in Alzheimer's

For the first time, researchers from the University of Zurich demonstrate a surprising effect of microglia, the scavenger cells of the brain: If these cells lack the TDP-43 protein, they not only remove Alzheimer's plaques, ...

Alzheimer's disease & dementia

'Pac-Man' gene implicated in Alzheimer's disease

A gene that protects the brain from the harmful build-up of amyloid-beta, one of the causative proteins implicated in Alzheimer's disease, has been identified as a new target for therapy by NeuRA researchers.

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