Buck Institute researchers have discovered and are developing a novel, non-invasive biomarker test that can be used to measure and track performance of senolytics: a class of drugs that selectively eliminate senescent cells. ...
Apr 2, 2021
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Scientists at The Wistar Institute identified a new mechanism of transcriptional control of cellular senescence that drives the release of inflammatory molecules that influence tumor development through altering the surrounding ...
Apr 1, 2021
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Through an analysis of cellular components (cell fractions) from malignant ascites (fluid buildup in the abdomen caused by gastric cancer), a research collaboration based in Kumamoto University (Japan) has demonstrated that ...
Mar 23, 2021
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Inhibiting a key enzyme that controls a large network of proteins important in cell division and growth paves the way for a new class of drugs that could stop glioblastoma, a deadly brain cancer, from growing.
Feb 12, 2021
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Cellular senescence, a state of permanent growth arrest, has emerged as a hallmark and fundamental driver of organismal aging. It is regulated by both genetic and epigenetic factors. Despite a few previously reported aging-associated ...
Jan 8, 2021
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Unraveling the links among obesity, aging, telomere lengths and metabolic diseases is the subject of the study published today in Nature Metabolism by a collaborative research team at The University of Texas Health Science ...
Dec 15, 2020
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How well women with cervical cancer respond to treatment and survive correlates with the level of 10 proteins in their blood that also are associated with a "zombie" cell state called senescence, Medical College of Georgia ...
Dec 7, 2020
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In human, the skin is one of the organs that exhibit early-onset aging-associated dysfunction. As a critical physical barrier, the skin is composed of a variety of cell types including fibroblasts and keratinocytes. Due to ...
Nov 27, 2020
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I recently visited an 83-year-old patient in the hospital after EMTs rushed her to the ER with an infected leg wound. Her ordeal started inconspicuously when she bumped into the sharp edge of a table and developed a small ...
Nov 24, 2020
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NAD+ (nicotinamide adenine dinucleotide), a key metabolite central to an efficient and healthy metabolism, declines with age. This previously unexplained phenomena is associated with numerous age-related diseases and has ...
Nov 16, 2020
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