Mammals have a poor ability to recover after a spinal cord injury, which can result in paralysis. A main reason for this is the formation of a complex scar associated with chronic inflammation that produces a cellular microenvironment ...
Jul 6, 2021
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442
New research from the University of Minnesota Medical School and colleagues at the Mayo Clinic reveals a possible new approach to preventing death and severe disease in elderly people infected with SARS-CoV-2.
Jun 8, 2021
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15
Scientists at UC San Francisco are learning how immune cells naturally clear the body of defunct—or senescent—cells that contribute to aging and many chronic diseases. Understanding this process may open new ways of treating ...
May 10, 2021
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377
Researchers have finally cracked the code of a bewildering pediatric disease that sets off a characteristic cytokine storm—a harmful immune system overaction resembling one that arises in COVID-19 cases—and can lead to ...
May 6, 2021
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65
Buck Institute researchers have discovered and are developing a novel, non-invasive biomarker test that can be used to measure and track performance of senolytics: a class of drugs that selectively eliminate senescent cells. ...
Apr 2, 2021
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177
Scientists at The Wistar Institute identified a new mechanism of transcriptional control of cellular senescence that drives the release of inflammatory molecules that influence tumor development through altering the surrounding ...
Apr 1, 2021
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Inhibiting a key enzyme that controls a large network of proteins important in cell division and growth paves the way for a new class of drugs that could stop glioblastoma, a deadly brain cancer, from growing.
Feb 12, 2021
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113
Cellular senescence, a state of permanent growth arrest, has emerged as a hallmark and fundamental driver of organismal aging. It is regulated by both genetic and epigenetic factors. Despite a few previously reported aging-associated ...
Jan 8, 2021
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254
Unraveling the links among obesity, aging, telomere lengths and metabolic diseases is the subject of the study published today in Nature Metabolism by a collaborative research team at The University of Texas Health Science ...
Dec 15, 2020
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64
NAD+ (nicotinamide adenine dinucleotide), a key metabolite central to an efficient and healthy metabolism, declines with age. This previously unexplained phenomena is associated with numerous age-related diseases and has ...
Nov 16, 2020
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444
