Some families call it a trial of faith. Others just call it a curse. The progressive neurological disease known as spinocerebellar ataxia 4 (SCA4) is a rare condition, but its effects on patients and their families can be ...
Apr 29, 2024
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Spinocerebellar ataxias are a group of neurodegenerative diseases characterized by the degeneration of Purkinje cells, a major class of neurons in the cerebellum. The resulting cerebellar dysfunction leads patients to experience ...
Oct 3, 2022
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A clinical trial conducted by Prof. Alexandra Durr's team (Sorbonne University.AP-HP) at the Paris Brain Institute and the Pitié-Salpêtrière Hospital AP-HP shows that despite the hopes raised in recent years, riluzole ...
Jan 19, 2022
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A new study led by University of California, Irvine researchers has confirmed a link between altered DNA repair and increased DNA damage associated with spinocerebellar ataxia type 7 (SCA7), a debilitating, sometimes deadly ...
Nov 30, 2021
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A research team from Kumamoto University, Japan has developed an animal model that reproduces motor dysfunction and cerebellar neurodegeneration similar to that in spinocerebellar ataxia (SCA) by inhibiting chaperone-mediated ...
Sep 23, 2020
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Spinocerebellar ataxias are diseases of the nervous system associated with a loss of motor coordination. A European research alliance headed by the German Center for Neurodegenerative Diseases (DZNE) and the University of ...
Aug 19, 2020
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Bristol scientists have discovered a novel pathology that occurs in several human neurodegenerative diseases, including Huntington's disease.
Jun 30, 2020
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For the first time, the UNC School of Medicine lab of Jonathan Schisler, MS, Ph.D., linked the specific biochemical changes to a protein called CHIP to specific disease characteristics of patients with a wide range of rare ...
Nov 6, 2019
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Elongated segments of DNA cause Huntington's disease and certain other disorders of the brain. Researchers funded by the SNSF have developed a method to determine the length of the mutated genes quickly and easily.
Jan 10, 2019
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Research from the University of Toronto has shown that in some neurodegenerative diseases, two hallmarks of cell aging – protein aggregation and a type of DNA instability – are linked. They were previously thought to ...
Nov 21, 2018
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