Oncology & Cancer

Mental illness elevated among Hodgkin lymphoma patients

Patients with Hodgkin lymphoma (HL) are more likely to suffer from mental-health and substance-abuse disorders than the general population. Calling for more attention to mental health, a study published August 2 in Cancer ...

Oncology & Cancer

Digital life coaching during stem cell transplantation

Research published in JMIR Formative Research reports that the authors launched a single-arm pilot study to investigate the feasibility of patient engagement with digital life coaching (DLC) during this intensive period.

HIV & AIDS

Fourth person 'cured' of HIV, but is a less risky cure in sight?

AIDS researchers announced on Wednesday that a fourth person has been "cured" of HIV, but the dangerous procedure for patients also battling cancer may be little comfort for the tens of millions living with the virus worldwide.

Oncology & Cancer

Diversity among bone marrow donors is needed

Bone marrow transplants are procedures that infuse healthy blood stem cells into your body to replace damaged or diseased bone marrow. Just like people in need of solid organ transplants, such as hearts or kidneys, people ...

Medical research

New mark for targeted leukemia treatment

Researchers led by the Francis Crick Institute have found that blocking a particular protein could offer a new way to target leukemic stem cells without causing harm to healthy stem cells.

Medical research

Chronic lung disease treatment hits speed bump

A promising avenue of research into chronic lung disease treatment has hit a speed bump, with a new study showing that 3D manufacturing mesenchymal stem cells (MSCs) may not be the panacea hoped for by researchers.

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Hematopoietic stem cell transplantation

Hematopoietic stem cell transplantation (HSCT) is the transplantation of blood stem cells derived from the bone marrow (in this case known as bone marrow transplantation) or blood. Stem cell transplantation is a medical procedure in the fields of hematology and oncology, most often performed for people with diseases of the blood, bone marrow, or certain types of cancer.

With the availability of the stem cell growth factors GM-CSF and G-CSF, most hematopoietic stem cell transplantation procedures are now performed using stem cells collected from the peripheral blood, rather than from the bone marrow. Collecting peripheral blood stem cells provides a bigger graft, does not require that the donor be subjected to general anesthesia to collect the graft, results in a shorter time to engraftment, and may provide for a lower long-term relapse rate.

Hematopoietic stem cell transplantation remains a risky procedure with many possible complications; it has traditionally been reserved for patients with life-threatening diseases. While occasionally used experimentally in nonmalignant and nonhematologic indications such as severe disabling auto-immune disease and cardiovascular disease, the risk of fatal complications appears too high to gain wider acceptance.

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