The tyrosine kinase MerTK plays a prominent role in the body's immune response. MerTK signaling helps "calm" the body's first line of immunity, the macrophage, while it performs the routine duties - clearing cells that die ...
Jul 8, 2013
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CHARGE syndrome is a severe developmental disorder affecting multiple organs. It affects 1 in 8500 newborns worldwide. The majority of patients carry a mutation in a gene called CHD7. How this single mutation leads to the ...
Jul 5, 2013
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Proteins and other therapeutic compounds injected directly into the blood stream tend to be broken down rapidly by the immune system. Now, researchers in Singapore have demonstrated in mice that the anticancer protein, interferon-α2a ...
Jul 3, 2013
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A number of drugs exist that can extend the lifespan of people with multiple myeloma (MM), but none of these medicines are curative. Thus, medical researchers continue to search for targets for new drug therapies as well ...
Jul 3, 2013
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Researchers at the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute have uncovered for the first time the vital role a popular protein plays in the stroma, the cell-lined area outside of a prostate tumor.
Jun 25, 2013
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A study led by researchers at The Ohio State University Comprehensive Cancer Center-– Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC–James) has identified a biochemical pathway in cancer ...
Jun 18, 2013
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According to the American Cancer Society, nearly 40,000 women in the United States will succumb to breast cancer this year. Most of these women will die not from the primary tumor but rather tumor recurrence – the reappearance ...
Jun 13, 2013
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(Medical Xpress)—Malignant cells can escape from primary tumors and colonize new sites in other tissues. In a new study, LMU researchers show how the transcription factor AP4 promotes the development of such metastatic ...
Jun 11, 2013
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(Medical Xpress)—A novel gene variant found in human and animal tissue may be a promising treatment for cancer, including breast and brain cancer, according to scientists from the Icahn School of Medicine at Mount Sinai. ...
Jun 7, 2013
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MET protein levels correlate strongly with epithelial-mesenchymal transition (EMT) phenotype, a treatment-resistant type of colorectal cancer and may be used as a surrogate biomarker, according to new research from The University ...
Jun 4, 2013
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