Oncology & Cancer
Skin cancer can spread in mice by hijacking the immune system
Scientists have uncovered molecules released by invasive skin cancer that reprogram healthy immune cells to help the cancer to spread.
Jan 31, 2019
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31
Melanoma
Oncology & Cancer
Combining three treatment strategies may significantly improve melanoma treatment
A study by a team led by a Massachusetts General Hospital (MGH) investigator finds evidence that combining three advanced treatment strategies for malignant melanoma—molecular targeted therapy, immune checkpoint blockade ...
Dec 12, 2018
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56
Oncology & Cancer
Targeting MC1R in metastatic melanoma
In 1960, scientists described the "Philadelphia chromosome" that causes chronic myeloid leukemia, and in 2001 the Food and Drug Administration approved the drug imatinib to disable the action of this cancer-causing genetic ...
Nov 26, 2018
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22
Oncology & Cancer
Study shows immunotherapy drug helps patients with metastatic melanoma
When melanoma turns metastatic, it spreads to the brain in more than 40% of patients. A study by Yale Cancer Center researchers published today in the Journal of Clinical Oncology (JCO) shows a checkpoint inhibitor immunotherapy ...
Nov 9, 2018
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85
Oncology & Cancer
How melanoma evades targeted therapies
Melanoma is the leading cause of death from skin cancer. Many patients develop metastatic disease that spreads to other parts of the body. One commonly used targeted therapy for metastatic melanomas works by attacking melanomas ...
Nov 6, 2018
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76
Oncology & Cancer
Single-cell analysis reveals how melanoma cells resist immunotherapy
Unleashing the immune system to fight tumors—an approach enabled by immunotherapy—has led to remarkable outcomes in some cancer patients, but in many more, cancer cells evade the treatment and continue to spread. Now, ...
Nov 2, 2018
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64
Oncology & Cancer
Fishing for new leads in a rare melanoma
Zebrafish are an emerging power tool in cancer research. They can be engineered to light up when certain genes turn on—capturing the moment when a cancer is initiated. Because they breed so quickly, they lend themselves ...
Nov 1, 2018
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91
Oncology & Cancer
Shedding light on 100-year-old cancer mystery
For almost a century, scientists have observed a strange behavior in cancer cells: They prefer a less-efficient pathway to produce energy. While normal cells utilize aerobic glycolysis to use glucose to produce 36 energy-storing ...
Sep 12, 2018
1
202
Oncology & Cancer
Study finds melanoma biomarkers predicting checkpoint blocker response
Scientists at Dana-Farber/Brigham and Women's Cancer Center (DF/BWCC) have identified biomarkers in melanoma that could help tailor immunotherapy treatments to maximize the benefits for patients while reducing the likelihood ...
Jul 18, 2018
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42
Oncology & Cancer
Scientists develop 'world first' melanoma blood test
Australian researchers said Wednesday they have developed a blood test for melanoma in its early stages, calling it a "world first" breakthrough that could save many lives.
Jul 18, 2018
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