Circadian rhythms have profound influence on metabolic output, study reveals
By analyzing the hundreds of metabolic products present in the liver, researchers with the UC Irvine Center for Epigenetics & Metabolism have discovered that circadian rhythms our own body clock greatly control the production of such key building blocks as amino acids, carbohydrates and lipids.
They identified more than 600 liver-originated metabolites, which are the chemical substances created by metabolism that sustain and promote cell health and growth. Approximately 60 percent of these metabolites were found to be dependent on the endogenous circadian clock many more than expected, as only about 15 percent of the body's genes are regulated by it.
Circadian rhythms over 24 hours govern fundamental biological and physiological processes in almost all organisms. They anticipate environmental changes and adapt certain bodily functions to the appropriate time of day. Disruption of these cycles can seriously affect human health.
Center for Epigenetics & Metabolism director Paolo Sassone-Corsi, lead author on the study and one of the world's preeminent researchers on circadian rhythms, said the liver metabolites reveal how the body clock through the main circadian gene, CLOCK orchestrates the interplay between metabolites and signaling proteins in much the same way a conductor leads a symphony.
"Metabolites and signaling proteins like the horns and strings in an orchestra need to be perfectly coordinated, and we've found that CLOCK provides that direction," he said.
Since external cues such as day-night lighting patterns and nutrition influence the circadian machinery, metabolites and their relationship to signaling proteins in cells seem to be acutely tied to circadian disruptions. This may help explain, Sassone-Corsi added, some of the primary physiological factors underlying obesity, high cholesterol and metabolic-based diseases like diabetes.
"This interplay has far-reaching implications for human illness and aging, and it is likely vital for proper metabolism," he said. Study results appear this week in the early online edition of the Proceedings of the National Academy of Sciences.
"By identifying the relationship between metabolites and the body clock, we have taken a first step toward a better understanding of how nutrients interact with our metabolism, giving researchers a new opportunity to spot the optimal times for us to get the fullest benefits from the foods we eat and the medications we take," added Kristin Eckel-Mahan, a UCI postdoctoral researcher in biological chemistry and study co-author.
Working with Metabolon Inc., Sassone-Corsi and Eckel-Mahan created the first liver metabolome the full set of metabolites. With this information, they partnered with Pierre Baldi, director of UCI's Institute for Genomics & Bioinformatics, and his graduate student Vishal Patel to analyze the data and build CircadiOmics, a Web-based data system that provides detailed profiles of the metabolites and related genes in the liver and the underlying networks through which they interact. The CircadiOmics address is http://circadiomics.igb.uci.edu.
"Within CircadiOmics, we were able to integrate this circadian metabolite data with multiple other data sources to generate the first comprehensive map of the liver metabolome and its circadian oscillations and develop regulatory hypotheses that have been confirmed in the laboratory," said Baldi, Chancellor's Professor of computer science. "CircadiOmics is being expanded with metabolic data about other tissues and conditions and will be invaluable to further our understanding of the interplay between metabolism and circadian rhythms in healthy and diseased states."
Provided by University of California - Irvine
- Circadian rhythm-metabolism link discovered Jul 24, 2008 | not rated yet | 0
- Internal body clock controls fat metabolism, study shows Nov 15, 2010 | not rated yet | 0
- Body clock regulates metabolism Mar 12, 2009 | not rated yet | 0
- The clock watcher: Circadian rhythms research is shedding light on the causes of disease and aging May 29, 2009 | not rated yet | 0
- Appetite, consumption controlled by clockwork genes at cross-purposes in flies Dec 06, 2009 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
1 hour ago Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
22 hours ago As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
Every day, their baby stopped breathing, his collapsed bronchus blocking the crucial flow of air to his lungs. April and Bryan Gionfriddo watched helplessly, just praying that somehow the dire predictions ...
Medical research 12 hours ago | 5 / 5 (2) | 0
The human gut is loaded with commensal bacteria – "good" microbes that, among other functions, help the body digest food. The gastrointestinal tract contains literally trillions of such cells, and yet the ...
Medical research 16 hours ago | 5 / 5 (3) | 0 |
Swiss scientists reveal the mechanism responsible for aging hidden deep within mitochondria—and dramatically slow it down in worms by administering antibiotics to the young.
Medical research 16 hours ago | 4.9 / 5 (7) | 0 |
On May 22, JoVE will publish details of a technique to measure the health of human genetic material in relation to a patient's age. The method is demonstrated by the laboratory of Dr. Gil Atzmon at New York's Albert Einste ...
Medical research 19 hours ago | not rated yet | 0
(Medical Xpress)—Scientists supported by the National Institutes of Health have a new theory as to why a woman's fertility declines after her mid-30s. They also suggest an approach that might help slow ...
Medical research 21 hours ago | not rated yet | 0 |
Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.
16 hours ago | 4.7 / 5 (3) | 0 |
Until now, little was scientifically known about the human potential to cultivate compassion—the emotional state of caring for people who are suffering in a way that motivates altruistic behavior.
13 hours ago | 5 / 5 (2) | 2 |
Existing research shows that bicyclists who wear helmets have an 88 percent lower risk of brain injury, but researchers at Boston Children's Hospital found that simply having bicycle helmet laws in place showed a 20 percent ...
5 hours ago | not rated yet | 0
(HealthDay)—Migraines and depression can each cause a great deal of suffering, but new research indicates the combination of the two may be linked to something else entirely—a smaller brain.
12 hours ago | 4 / 5 (2) | 0 |
A new approach for immunizing against influenza elicited a more potent immune response and broader protection than the currently licensed seasonal influenza vaccines when tested in mice and ferrets. The vaccine ...
13 hours ago | not rated yet | 0 |
In a series of lab experiments designed to unravel the workings of a key enzyme widely considered a possible trigger of rheumatoid arthritis, researchers at Johns Hopkins have found that in the most severe ...
15 hours ago | 5 / 5 (1) | 0 |