Researchers find cutaneous human papillomavirus infection a risk factor for skin cancer
Researchers at Moffitt Cancer Center and colleagues at the University of South Florida, the German Cancer Research Center in Heidelberg, and the International Agency for Research on Cancer in Lyon, France, conducted a case control study and found associations between having antibodies to certain types of cutaneous human papillomavirus (HPV) and a kind of skin cancer called squamous cell carcinoma (SCC).
Their study, the first case-control study to investigate the association between SCC and cutaneous HPV types belonging to five different genera, appeared in a recent issue of Cancer Epidemiology, Biomarkers & Prevention, a journal published by the American Association for Cancer Research. The research was supported by a grant from the James and Esther King New Investigator grant through the Florida Department of Health and by the Miles for Moffitt Foundation Funds.
"Squamous cell carcinoma of the skin is the second most frequently occurring cancer among Caucasians in the United States, and the numbers of cases continue to rise," said study lead author Dana E. Rollison, Ph.D., Moffitt associate member, vice president and chief health information officer. "Risk factors for SCC include ultraviolet radiation exposure via the sun, older age, light skin and suppressed immune system."
According to the researchers, evidence has been emerging that cutaneous human papillomavirus infection (not the mucosal HPV infection that is associated with cervical cancers) may be an additional risk factor for SCC. Their study investigated antibodies to cutaneous HPV types in five different genera - alpha, beta, gamma, mu and nu - in blood samples from patients with SCC and a control group that did not have SCC.
The study was conducted using 173 SCC cases from a university dermatology clinic and 300 controls who screened negative for skin cancer. Tumor tissue from 159 SCC cases was tested for the presence of cutaneous HPV infection.
The researchers found that SCC was significantly associated with antibodies to HPV 10 in genus alpha and HPV types 8 and 17 in genus beta. Additional associations were found between antibodies to beta HPV types 5 and 24 when SCC cases with those same HPV types in their tumors were compared to controls.
"While our current study provides evidence for an association between genus-beta HPV and SCC, the exact mechanism by which the association exists is still unclear," explained Rollison.
Some researchers hypothesize that infection with the genus-beta HPV has an effect on the repair of DNA in sun-damaged skin, an effect that subsequently leads to an accumulation of mutations that could predispose people to SCC formation.
The study, Rollison said, was unique in that it measured cutaneous HPV types in five different genera and investigated correlations between cutaneous HPV antibodies in the blood and HPV infection in the tumor.
"We hope that this study, aimed at identifying the role of cutaneous HPV infection in SCC, will lead to improved knowledge about who is at risk for SCC and the development of new means of prevention," concluded Rollison and the researchers.
Journal reference: Cancer Epidemiology, Biomarkers & Prevention
- Sun exposure and cutaneous HPV infection found synergistic in skin cancers Jun 25, 2012 | not rated yet | 0
- HPV infection highly prevalent among organ transplant recipients Jul 12, 2011 | not rated yet | 0
- Study examines chronic inflammation in oral cavity and HPV status of head and neck cancers Jun 18, 2012 | not rated yet | 0
- Researchers find smoking is strongly associated with squamous cell carcinoma among women Dec 08, 2011 | not rated yet | 0
- Periodontitis linked to HPV-positive head, neck tumors Jun 20, 2012 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
How can there be a term called "intestinal metaplasia" of stomach
17 hours ago Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
- More from Physics Forums - Medical Sciences
More news stories
The gap between life expectancy in patients with a mental illness and the general population has widened since 1985 and efforts to reduce this gap should focus on improving physical health, suggest researchers in a paper ...
Cancer 6 hours ago | not rated yet | 0
By studying the roles two proteins, thrombospondin-1 and prosaposin, play in discouraging cancer metastasis, a trans-Atlantic research team has identified a five-amino acid fragment of prosaposin that significantly reduces ...
Cancer 7 hours ago | not rated yet | 0
A novel transcriptome-based classification of colon cancer that improves the current disease stratification based on clinicopathological variables and common DNA markers is presented in a study published in PLOS Medicine this w ...
Cancer 7 hours ago | not rated yet | 0
A study of veterans at high risk for developing lung cancer shows that low-dose computed tomography (LDCT) can be highly effective in helping clinicians spot tiny lung nodules which, in a small number of patients, may indicate ...
Cancer 9 hours ago | not rated yet | 0
An attack on glioblastoma brain tumor cells that uses a modified poliovirus is showing encouraging results in an early study to establish the proper dose level, researchers at Duke Cancer Institute report.
Cancer 11 hours ago | not rated yet | 0
(Medical Xpress)—Native peoples in regions where cameras are uncommon sometimes react with caution when their picture is taken. The fear that something must have been stolen from them to create the photo ...
13 hours ago | 4.2 / 5 (5) | 0 |
(Medical Xpress)—Despite spending billions of dollars on research and development, drug companies have been unable to come up with effective treatments for dementia and Alzheimer's Disease (AD). Now, A. ...
11 hours ago | 4.9 / 5 (9) | 0 |
An experimental sleeping pill from US drug company Merck is effective at helping people fall and stay asleep, according to reviewers at the US Food and Drug Administration, which could soon approve the new drug.
6 hours ago | 3 / 5 (2) | 0
Activating an enzyme known to play a role in the anti-aging benefits of calorie restriction delays the loss of brain cells and preserves cognitive function in mice, according to a study published in the May ...
7 hours ago | 5 / 5 (3) | 0 |
Australian scientists have charted the path of insulin action in cells in precise detail like never before. This provides a comprehensive blueprint for understanding what goes wrong in diabetes.
13 hours ago | 4.5 / 5 (6) | 0 |
A drug commonly used to treat depression and anxiety may improve a stress-related heart condition in people with stable coronary heart disease, according to researchers at Duke Medicine.
8 hours ago | 5 / 5 (1) | 0 |