KRAS mutations predict shorter survival in lung cancer

July 26, 2012
KRAS mutations predict shorter survival in lung cancer
For patients with advanced lung adenocarcinomas, KRAS mutations predict shorter survival, according to a study published online July 18 in Cancer.

(HealthDay) -- For patients with advanced lung adenocarcinomas, KRAS mutations predict shorter survival, according to a study published online July 18 in Cancer.

Melissa L. Johnson, M.D., from Northwestern University in Chicago, and colleagues examined the prognostic significance of KRAS using data from 1,036 patients (59 percent women; 33 percent never-smokers) with advanced lung adenocarcinomas with known and KRAS status, who were evaluated between 2002 and 2009.

The researchers found that the patients had a median age of 65 years, and 81 percent had a Karnofsky performance status of 80 percent or greater. EGFR mutations correlated with longer overall survival (hazard ratio, 0.60; P < 0.001) and KRAS mutations with shorter survival (hazard ratio, 1.21; P = 0.048), in multivariate analysis.

"In conclusion, we report here that the presence of a KRAS mutation is a poor for patients with lung adenocarcinomas," the authors write. "Because patients with KRAS mutations have a distinct clinical course that results in shorter survival, they should be evaluated separately in clinical trials. We recommend including KRAS testing in upfront mutation analyses along with testing for EGFR mutations and EML4-ALK to prospectively identify these patients in the clinic."

Several authors disclosed to pharmaceutical companies.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

EGFR essential for the development of pancreatic cancer

September 15, 2011

The epidermal growth factor receptor (EGFR) gene is essential for KRAS-driven pancreatic cancer development, according to study results presented at the Second AACR International Conference on Frontiers in Basic Cancer Research, ...

Antifolates show promise against NSCLC subtype

November 14, 2011

Patients with non-small cell lung cancer who have mutations in the KRAS gene should respond well to the antifolate class of drugs, according to results of a recent study conducted by Quintiles comparing human lung cancer ...

Gene-based test identifies poor-prognosis colon cancers

March 9, 2012

(HealthDay) -- A sensitive and specific gene-based classifier can be used to identify BRAF mutant colon cancer tumors and a subpopulation of BRAF wild-type tumors with poor prognosis, according to a study published March ...

Recommended for you

Strange circular DNA may offer new way to detect cancers

July 30, 2015

Strange rings of DNA that exist outside chromosomes are distinct to the cell types that mistakenly produced them, researchers have discovered. The finding raises the tantalizing possibility that the rings could be used as ...

New treatment options for a fatal leukemia

July 27, 2015

In industrialized countries like in Europe, acute lymphoblastic leukemia is the most common form of cancer in children. An international research consortium lead by pediatric oncologists from the Universities of Zurich and ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.