Transcription factor Lyl-1 critical in producing early T-cell progenitors
A transcription factor called Lyl-1 is necessary for production of the earliest cells that can become T-cells, critical cells born in the thymus that coordinate the immune response to cancer or infections, said a consortium of researchers led by those from Baylor College of Medicine in a report in the journal Nature Immunology.
These earliest progenitors (called early T lineage progenitor cells) are the first cells that can be identified as being on the road to becoming T-cells, said Dr. Margaret Goodell, director of the Stem Cells and Regenerative Medicine Center of Baylor College of Medicine. Without Lyl-1, only a few of these early T lineage progenitor cells get made.
"This finding gives us insight into the biology of these progenitor cells," said Goodell, a professor of pediatrics at BCM and a member of the Center for Cell and Gene Therapy at BCM, Texas Children's Hospital and The Methodist Hospital.
Dr. Fabian Zohren, a post-doctoral student in Goodell's laboratory, found that mice lacking the gene for this factor had a T-cell deficiency and in particular, too few of these early progenitor cells.
"It showed that those early T lineage progenitor cells are really dependent on Lyl-1 for their generation," said Goodell, who is also corresponding author of the report. "We think that Lyl-1 controls a program that allows survival and expansion of these critical progenitors."
The finding may have particular import in understanding a form of leukemia known as T-cell acute lymphoblastic leukemia. The researchers found that the forms of the disease that have the worst prognosis are those in which the cancer cells resemble these early T lineage progenitor cells. These cells also have high levels of Lyl-1.
One possibility is the T-cell progenitors in patients with this type of T-cell leukemia continue to express Lyl-1, so continue to be programmed to expand. The excess Lyl-1 prevents the early T lineage progenitor cells from differentiating into active T-cells. Goodell said a recent grant from the Alex's Lemonade Stand Foundation will help test that hypothesis.
Journal reference: Nature Immunology
Provided by Baylor College of Medicine
- 'Fingerprints' help find genes involved in differentiation Nov 14, 2007 | not rated yet | 0
- 'Sister' factors promote survival of blood-system stem cells Feb 05, 2009 | not rated yet | 0
- Theory of single stem cell for blood components challenged Mar 04, 2010 | not rated yet | 0
- Targeting cell pathway may prevent relapse of leukemia Mar 25, 2010 | not rated yet | 0
- Blood progenitor cells receive signals from niche cells and the daughter blood cells they create Dec 22, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Electric field between parallel plate capacitor
57 minutes ago If you have an infinite non-conducting plate, the electric field just outside is equal to sigma / 2*epsilon. The electric field just outside a...
Why angle of projectile has 2 solutions?
1 hour ago I have the final answer of: sin2(theta) = 0.871 why does (theta) = 30.3 deg OR (theta) = 59.7 deg I get why this could be physically, but...
How much negative charge do I accumulate by touching the earth?
3 hours ago The Earth carries a negative electric charge of roughly 500 thousand Coulombs (according to different sources I've seen). If I touch the Earth I...
Indeterminism in Classical Physics
8 hours ago I was reading the Roger Penrose book Emperor's New Mind and he was explaining the determinism in Newtonian mechanics. He says that if we consider...
Current in two wires
9 hours ago Wire A and B, which have the same cross-sectional area are connected in series. There is a p.d. V across the whole wire. Suppose the two wires...
understanding the dipole model for Rayleigh scattering
11 hours ago Hello. I am currently studying scattering theory in detail for my BSc thesis, and I'm starting with Rayleigh scattering. I'm following Scattering...
- More from Physics Forums - Classical Physics
More news stories
Kate O'Reilly's spring allergy survival kit includes the usual stuff - nasal sprays, allergy pills and a box of tissues. This season, she's added a new weapon to her line of defense: an app on her smartphone.
Immunology 1 hour ago | not rated yet | 0
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...
Immunology 3 hours ago | 5 / 5 (2) | 0 |
(Medical Xpress)—Scientists at Emory Vaccine Center have shown that an immune regulatory molecule called IL-21 is needed for long-lasting antibody responses in mice against viral infections.
Immunology May 23, 2013 | 5 / 5 (1) | 0 |
Human breastmilk responds quickly to protect the child when there is an infection in mothers or babies, according to new international research led by The University of Western Australia.
Immunology May 23, 2013 | 5 / 5 (1) | 0
Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...
48 minutes ago | not rated yet | 0 |
Talking on a hands-free device while behind the wheel can lead to a sharp increase in errors that could imperil other drivers on the road, according to new research from the University of Alberta.
17 minutes ago | not rated yet | 0
(AP)—Government health officials are investigating several health problems reported with potentially contaminated medications made by a Tennessee specialty pharmacy.
43 minutes ago | not rated yet | 0
(Medical Xpress)—A new study by researchers in the US has shown that an ancient virus can be modified to help in the fight against the simian immunodeficiency virus SIV, which is the equivalent in monkeys ...
6 hours ago | 5 / 5 (3) | 0 |
Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences, according to a study from UCL.
3 hours ago | 5 / 5 (1) | 0 |