Researchers make old muscles young again in attempt to combat aging

An international team of scientists have identified for the first time a key factor responsible for declining muscle repair during ageing, and discovered how to halt the process in mice with a common drug. Although an early study, the findings provide clues as to how muscles lose mass with age, which can result in weakness that affects mobility and may cause falls.

The study, to be published in the journal Nature, involved researchers from King's College London, Harvard University and Massachusetts General Hospital.

The study looked at stem cells found inside muscle – which are responsible for repairing injury – to find out why the ability of muscles to regenerate declines with age. A dormant reservoir of stem cells is present inside every muscle, ready to be activated by and injury to repair any damage. When needed, these cells divide into hundreds of new that repair the muscle. At the end of the repairing process some of these cells also replenish the pool of dormant stem cells so that the muscle retains the ability to repair itself again and again.

The researchers carried out a study on old and found the number of dormant stem cells present in the pool reduces with age, which could explain the decline in the muscle's ability to repair and regenerate as it gets older. When these old muscles were screened the team found high levels of FGF2, a that has the ability to stimulate cells to divide. While encouraging stem cells to divide and repair muscle is a normal and crucial process, they found that FGF2 could also awaken the dormant pool of stem cells even when they were not needed. The continued activation of dormant stem cells meant the pool was depleted over time, so when the muscle really needed stem cells to repair itself the muscle was unable to respond properly.

Following this finding, the researchers attempted to inhibit FGF2 in old muscles to prevent the stem cell pool from being kick-started into action unnecessarily. By administering a common FGF2 inhibitor drug they were able to inhibit the in the number of muscle stem cells in the mice.

Dr Albert Basson, Senior Lecturer at the King's College London Dental Institute, said: 'Preventing or reversing muscle wasting in old age in humans is still a way off, but this study has for the first time revealed a process which could be responsible for age-related muscle wasting, which is extremely exciting.

'The finding opens up the possibility that one day we could develop treatments to make old muscles young again. If we could do this, we may be able to enable people to live more mobile, independent lives as they age.'

Dr Andrew Brack, senior and corresponding author of the study from Harvard University, said: 'Analogous to the importance of recovery for athletes training for a sporting event, we now know that it is essential for adult stem cells to rest between bouts of expenditure. Preventing stem cell recuperation leads to their eventual demise.'

Kieran Jones, co-author of the study from King's, added: 'We do not yet know how or why levels of the protein FGF2 increase with , triggering to be activated when they are not needed. This is something that needs to be explored.

'The next step is to analyse old muscle in humans to see if the same mechanism could be responsible for stem cell depletion in human fibres, leading to loss of mass and wastage.'

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Sonhouse
5 / 5 (4) Sep 26, 2012
They did not want anyone to know exactly which drug they were talking about apparently, but here is a reference to one such:

Recent observations have shown the ability of the soluble pattern recognition receptor long-pentraxin-3 (PTX3) to bind FGF2, thus acting as a FGF2 antagonist. PTX3 binds FGF2 with high affinity and specificity. This interaction prevents the binding of FGF2 to its cognate tyrosine kinase receptors, leading to inhibition of the angiogenic activity of the growth factor. Further, preliminary observations support the hypothesis that PTX3 may inhibit FGF2-mediated tumor angiogenesis and growth. The identification of the FGF2-binding domain in the unique N-terminal extension of PTX3 has allowed the design of PTX3-derived synthetic peptides endowed with significant antiangiogenic activity in vitro and in vivo. These findings may provide the basis for the development of novel antiangiogenic FGF2 antagonists, with potential implications for cancer therapy.
Sonhouse
5 / 5 (2) Sep 26, 2012
The above is from this print:

http://www.ncbi.n...20167562
Mike_Massen
2 / 5 (4) Sep 26, 2012
I thought this article might mention something re 711 the anti glycation (artificial) chemical where proteins bind to sugars as part of aging... And how this new compound can combat it with some amazing results in rats and mice years ago now all sorts of odd companies claim 711 is in their mix, when it cant be !
VendicarD
1 / 5 (8) Sep 26, 2012
This research is in direct opposition to God's design.

If God didn't want people to grow old and feeble, he wouldn't make them grow old and feeble.

No one taking a drug that violates God's will is going to get into heaven. They will spend all eternity burning in eternal hell fire.

po6ert
1 / 5 (1) Sep 26, 2012

Rosuvastatin is probably the drug they are referring to
obviously is a prime example of god's design
SteveL
4 / 5 (4) Sep 26, 2012
This research is in direct opposition to God's design.

If God didn't want people to grow old and feeble, he wouldn't make them grow old and feeble.

No one taking a drug that violates God's will is going to get into heaven. They will spend all eternity burning in eternal hell fire.

Or one could argue that if "God" didn't want us to use our brains we wouldn't have been provided with them. Since I have a brain and the ability to use it, I plan to.
When the space shuttle Challenger blew up a guy told me basically the same thing about how if God had intended mankind to be in space He would have put us there. That was the closest I have come to giving someone a black eye in many, many years. Fortunately that brain we were discussing earlier took back over. :)
Lantern5
1.7 / 5 (6) Sep 26, 2012
Thank you, thank you very much for the info, but we must be sure which is the drug in question, you mention the drug has some side effects: Headache, nausea, abdominal pain, and CPK elevations of transaminases in blood disorders of memory and perhaps even risk for hepatitis.
If not for continuous use, the risk is acceptable, but it would be great to find out what the real medicine that is used.
If true what the article says, the drug could be used to regenerate the body after a serious accident.
Shabs42
1 / 5 (2) Sep 27, 2012
This research is in direct opposition to God's design.

If God didn't want people to grow old and feeble, he wouldn't make them grow old and feeble.

No one taking a drug that violates God's will is going to get into heaven. They will spend all eternity burning in eternal hell fire.



You're a nudist, a hypocrite, or bound for hell. I hope it's not just the middle one.
Waaalt
2 / 5 (8) Sep 27, 2012
You're a nudist, a hypocrite, or bound for hell. I hope it's not just the middle one.


Atheist nerds post here and all over the internet pretending to be the worst sort of fundamentalists to discredit religion, a belief in god, etc in general, as part of their own hobby as an amateur propagandist.

I mean come on, think about it. What kind of sheltered technophobe religious fundamentalists hang out on the internet all day posting comments to science news stories?

Those people, to the extent that they actually exist, don't even have computers.
atomsk
2 / 5 (4) Sep 27, 2012
...
If God didn't want people to grow old and feeble, he wouldn't make them grow old and feeble.
...

If God wanted you to use the internet...
he didn't want you to use it (trust me I read the bible), so stop posting here.
VendicarD
not rated yet Sep 27, 2012
It was the demon Lucifer who tricked man into eating from the tree of knowledge.

And for that Crime, Man was forever cast out of paradise by God.

"Or one could argue that if "God" didn't want us to use our brains we wouldn't have been provided with them." - SteveL

God wants blind, unthinking obedience.

Science is the work of the AntiChrist.
Trenchant
1.8 / 5 (5) Sep 27, 2012
While I can see how quality of life can be improved, I do not see this as life extending. Anabolic steroids would be a significant life extender if this were the case. For the foreseeable future, avoiding a sedentary lifestyle will be superior to a drug for quality of life. Though for medical purposes, this is interesting research.

Shabs42, you say "nudist" like it's a bad thing. Don't knock it til you've tried it. Naked won't make you go to hell.
corymp
5 / 5 (1) Sep 27, 2012
It was the demon Lucifer who tricked man into eating from the tree of knowledge.

And for that Crime, Man was forever cast out of paradise by God.

"Or one could argue that if "God" didn't want us to use our brains we wouldn't have been provided with them." - SteveL

God wants blind, unthinking obedience.

Science is the work of the AntiChrist.

If learning is wrong, why are you on this site?
VendicarD
not rated yet Sep 27, 2012
I am attempting to save your Godless souls that Lucifer has turned from the loving dictates of God.

Haven't you read the book of Genesis?

ScooterG
1 / 5 (5) Sep 27, 2012
I wonder if these cells can be addressed directly by tapping (aka Emotional Freedom Technique)? Won't hurt anything to try, and might help speed injury recovery.

For the curious, the best site I've found for EFT information is mercola com.
Mike_Massen
1 / 5 (4) Sep 27, 2012
VendicarD please stop pretending, either that or you have woken up on the wrong side of the bed (again)...
I am attempting to save your Godless souls that Lucifer has turned from the loving dictates of God.
Haven't you read the book of Genesis?


Jokes over, too much noise...
jonnyboy
1 / 5 (6) Sep 29, 2012
This research is in direct opposition to God's design.

If God didn't want people to grow old and feeble, he wouldn't make them grow old and feeble.

No one taking a drug that violates God's will is going to get into heaven. They will spend all eternity burning in eternal hell fire.


what a Tard.
rwinners
3 / 5 (2) Oct 01, 2012
This research is in direct opposition to God's design.

If God didn't want people to grow old and feeble, he wouldn't make them grow old and feeble.

No one taking a drug that violates God's will is going to get into heaven. They will spend all eternity burning in eternal hell fire.



Who's god?
theloxleycountryclub
not rated yet Oct 01, 2012
Ok. But it's well known that a protein enriched diet AND a sensible routine of resistance training successfully combats, and in some cases reverses, age-related muscle atrophy (sarcopenia). A study of mature bodybuilders suggest this might be the case.

So what effect do these drug free activities have on FGF2 and the dormant muscle stem cells?

dutchman
not rated yet Oct 01, 2012
It was the demon Lucifer who tricked man into eating from the tree of knowledge.
And for that Crime, Man was forever cast out of paradise by God.
"Or one could argue that if "God" didn't want us to use our brains we wouldn't have been provided with them." - SteveL
God wants blind, unthinking obedience.
Science is the work of the AntiChrist.

Since all these quotes are a throwback to Middle Ages and the Inquisition, I must assume this is all tongue-in-cheek....
SteveL
not rated yet Oct 01, 2012
Yeah, VD just likes stirring the pot and yanking on chains to see who will bite.