Stemming the spread of cancer
Okayama University's Masaharu Seno and colleagues have demonstrated in vitro the development of cancer stem cells (CSCs) from a type of normal stem cell exposed to their hypothetical microenvironment of a tumor.
Cancer stem cells (CSCs) have been proposed as an explanation for the spread of cancer. These cells are tumorigenic and have the capacity of both self-renewal and differentiation into a range of various cell types. In this concept, malignant tumors provide heterogeneous aspects derived from CSCs as well as normal stem cells provide tissue specific phenotype in response to their microenvironment.
Spheroid GFP.Researchers have now demonstrated in vitro the development of CSCs from a type of normal stem cell exposed to their hypothetical microenvironment of a tumor. The results are the work of a group of scientists led by Masaharu Seno, a professor of Okayama University, with his collaborators in China and the US.
The researchers cultured mouse induced pluripotent stem (miPS) cells in a conditioned medium obtained from a number of mouse cancer cell lines. Finally, a population of stem cells was kept undifferentiated and proliferating while other stem cells differentiated into specialized cells, which were incapable of proliferation any more.
Immunostain.Since the survived miPS cells treated with the conditioned medium were found malignantly tumorigenic in vivo, they concluded that the cells could be defined as CSCs . "The model of CSCs and the procedure of their establishment will help study the genetic alterations and the secreted factors in the tumor microenvironment which convert miPS cells to CSCs," explain the authors. The work should help breakthrough towards the development of new therapies to combat cancer.
More information: Ling Chen et al., A model of cancer stem cells derived from mouse induced pluripotent stem cells. PLoS One 7, e33544 (2012). DOI: 10.1371/journal.pone.0033544
Journal reference: PLoS ONE
Provided by Okayama University
- Cancer stem cell subpopulation drives metastasis of human pancreatic cancer Sep 12, 2007 | not rated yet | 0
- Trapping prostate cancer cells to keep them from spreading provides hope Mar 10, 2011 | not rated yet | 0
- Disarming Specialized Stem Cells Might Combat Deadly Ovarian Cancer Jan 27, 2010 | not rated yet | 0
- Researchers attack stem cells that cause colon cancer Apr 28, 2010 | not rated yet | 0
- Discovery halts breast cancer stem cells Nov 23, 2010 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
3 hours ago Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
23 hours ago As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
(HealthDay)—The American Cancer Society, which is celebrating on Wednesday a century of fighting a disease once viewed as a death sentence, is making a pledge to put itself out of business.
Cancer 13 hours ago | not rated yet | 0
National Lung Screening Trial (NLST) investigators also conclude that the 20 percent reduction in lung cancer mortality with low-dose computed tomography (LDCT) versus chest X-ray (CXR) screening previously reported in the ...
Cancer 14 hours ago | not rated yet | 0
Researchers have developed a new drug delivery system that allows inhalation of chemotherapeutic drugs to help treat lung cancer, and in laboratory and animal tests it appears to reduce the systemic damage ...
Cancer 17 hours ago | not rated yet | 0 |
When turned on, the gene p53 turns off cancer. However, when existing drugs boost p53, only a few tumors die – the rest resist the challenge. A study published in the journal Cell Reports shows how: tumors that live even i ...
Cancer 17 hours ago | not rated yet | 0 |
Study leader, Professor John Mathews from the University of Melbourne said this small increase in cancer risk must be weighed against the undoubted benefits from CT scans in diagnosing and monitoring disease.
Cancer 22 hours ago | not rated yet | 0
US teen births have dropped to a record low, but the country still has one of the highest rates among developed nations, the US Centers for Disease Control and Prevention said Thursday.
54 minutes ago | not rated yet | 0
Swiss scientists reveal the mechanism responsible for aging hidden deep within mitochondria—and dramatically slow it down in worms by administering antibiotics to the young.
18 hours ago | 4.9 / 5 (9) | 1 |
Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.
18 hours ago | 4.7 / 5 (3) | 0 |
Until now, little was scientifically known about the human potential to cultivate compassion—the emotional state of caring for people who are suffering in a way that motivates altruistic behavior.
15 hours ago | 5 / 5 (2) | 2 |
Existing research shows that bicyclists who wear helmets have an 88 percent lower risk of brain injury, but researchers at Boston Children's Hospital found that simply having bicycle helmet laws in place showed a 20 percent ...
7 hours ago | not rated yet | 0
(HealthDay)—Migraines and depression can each cause a great deal of suffering, but new research indicates the combination of the two may be linked to something else entirely—a smaller brain.
15 hours ago | 4.3 / 5 (3) | 0 |