Three unique genes found to influence body size and obesity in people of African ancestry

Researchers from Dartmouth's Institute for Quantitative Biomedical Sciences (iQBS) and the Center for Genomic Medicine have helped to discover three unique genetic variations that influence body size and obesity in men and women of African ancestry. This study, a meta-analysis that examined 3.2 million genetic variants in over 30,000 people with African heritage for links to body-mass index or BMI—by professors Jason Moore, Christopher Amos and Scott Williams—was the largest ever done on this population to date. The study was published online in April 2013 by Nature Genetics, and will be printed in the journal's June 2013 issue. The large-scale genetic analysis demonstrated the utility of examining ancestrally diverse populations for clues as to why some groups seem more prone than others to physical problems such as obesity.

Nearly 50 percent of African-American adults in the U.S. are clinically obese (with BMI >=30), compared to 35 percent of non-Hispanic white adults. One large U.S. study found that the incidence of morbid or extreme "class 3" (BMI >=40) was highest among black women. Obesity is a worldwide health epidemic, associated with higher cardiovascular disease, diabetes and mortality, and lower quality of life. The study done by Moore, Amos, and Williams—also from the Norris Cotton Cancer Center (NCCC)—and colleagues showed that people from different populations share similar that impact body size (people with shared 32 gene variants previously associated with BMI in European and ). Yet the study also revealed that people with African ancestry possess three genetic variations that work in concert with environmental factors to impact BMI. This knowledge may help scientists to understand, and clinicians to better prevent or treat, obesity in this population.

The authors agree that both genes and environment play a role in obesity. Jason H. Moore, PhD, Third Century Professor, professor of genetics, and director of the iQBS, says, "I would love to stress that this paper is really just a start or a foundation for understanding the role of genetic variation in obesity. We expect obesity to be influenced by hundreds, if not thousands of genes and many, many environmental factors. While some genetic variants are likely to increase or decrease weight in all people, most are likely to influence weight in specific people depending on their genetic background and their unique environmental history including diet, toxic metal exposure, exercise, etc. We will not fully understand the genetics of obesity until we can fully investigate these context-dependent genetic effects."

Christopher Amos, PhD, director of the Center for Genomic Medicine, associate director for Population Sciences at NCCC, and professor of community and family medicine, explains that in African-Americans, genes played a greater role in causing increased BMI than in Caucasians. He says, "To date, the effects in both African-American and Caucasian participants are too small to explain much of the genetic variability in obesity rates, and this may be because the variation reflects both genetic and environmental contributions. Since the environmental factors have not been studied, the actual contribution from genetic factors may be greatly underestimated." Subsequent research may clarify how much of a role genes play in promoting obesity, and what might be done to reduce its incidence in vulnerable populations.

Unfortunately, obesity is common not only among African-Americans but among Africans as well. Scott Williams, PhD, professor of genetics and founding director of the Center for Integrative Biomedical Sciences in iQBS, says, "In Africa, the World Health Organization has predicted several hundred million new cases of obesity by 2020 (from mid 2000s). In our cohort in Ghana, roughly 25-30 percent of women were obese by U.S. criteria. In South Africa it is even worse."

Williams studies diseases that are distributed among human populations to examine the role that genetics plays in health disparities. He conducts research on within Africa, especially as it applies to diseases that affect people of African descent more frequently. This research "has helped to illuminate human evolutionary history and serves to bring disease presentation into an evolutionary perspective," says Williams.

Jason Moore, who is also associate director for bioinformatics at NCCC and a professor of community and family medicine, adds that, "The investment in infrastructure and personnel that we have put in place over the last three years at Dartmouth will make it possible for us locally to investigate these important human genetics questions."

Moore continues, "Christopher Amos, Scott Williams and I each bring unique research expertise to the table. Christopher Amos brings statistical genetics and genetic epidemiology; Scott Williams brings population and evolutionary genetics. I bring computational genetics and bioinformatics. Each of these pieces is critical for carrying out the kind of studies that are represented in this paper." The three authors currently work on grants to study the impact of genes on bladder cancer, visual diseases, cardiovascular diseases, infectious diseases, and Alzheimer's disease (Moore); lung cancer and melanoma (Amos); and cardiovascular disease risk, hypertension and preterm birth (Williams).

Following the publication of this paper, Jason Moore will chair the 6th Annual Integrative Biology Symposium April 23-24, hosted at Dartmouth by iQBS. The theme this year is obesity and human health.

add to favorites email to friend print save as pdf

Related Stories

Dartmouth researchers get personal with genetics

Sep 15, 2009

Two recent studies by Dartmouth researchers use individual genetic data to reveal the powers and limits of our current understanding of how the genome influences human health and what genes can reveal about the ancestry of ...

New genes discovered for adult BMI levels

Oct 25, 2012

A large international study has identified three new gene variants associated with body mass index (BMI) levels in adults. The scientific consortium, numbering approximately 200 researchers, performed a meta-analysis of 46 ...

Large-scale analysis identifies 32 genetic loci for obesity

Oct 11, 2010

An international team of researchers has identified 18 new genetic loci associated with obesity assessed by BMI, and confirmed a link between obesity and 14 previously known loci. Almost 250,000 individuals were included ...

New obesity, height genes identified

Apr 08, 2013

(Medical Xpress)—Busselton residents and researchers from The University of Western Australia have helped a worldwide scientific collaboration identify new genes associated with height and obesity.

Recommended for you

Stress reaction may be in your dad's DNA, study finds

7 hours ago

Stress in this generation could mean resilience in the next, a new study suggests. Male mice subjected to unpredictable stressors produced offspring that showed more flexible coping strategies when under ...

More genetic clues found in a severe food allergy

8 hours ago

Scientists have identified four new genes associated with the severe food allergy eosinophilic esophagitis (EoE). Because the genes appear to have roles in other allergic diseases and in inflammation, the ...

Brain-dwelling worm in UK man's head sequenced

Nov 20, 2014

For the first time, the genome of a rarely seen tapeworm has been sequenced. The genetic information of this invasive parasite, which lived for four years in a UK resident's brain, offers new opportunities ...

User comments

Adjust slider to filter visible comments by rank

Display comments: newest first

Chromodynamix
1 / 5 (1) Apr 23, 2013
For tens of thousands of years genetic selection has been taking place among Africans selecting those best to survive drought conditions and shortages of food. In times of plenty fat is deposited mainly around the posterior. Those with ample posteriors were best able to survive drought conditions. It is no coincidence that African tribes exhibit and indeed revere fat posteriors, and this is the primary reason that obesity is most accentuated in that area in African Americans.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.