Antipsychotics induce insulin resistance without weight gain

July 18, 2013
Antipsychotics induce insulin resistance without weight gain
Atypical antipsychotic drugs induce insulin resistance even in the absence of weight gain and mechanisms regulating eating behavior, according to a study published online July 8 in Diabetes.

(HealthDay)—Atypical antipsychotic drugs induce insulin resistance even in the absence of weight gain and mechanisms regulating eating behavior, according to a study published online July 8 in Diabetes.

To examine whether have detrimental metabolic effects independent of weight gain or , Karen L. Teff, Ph.D., from the Monell Chemical Senses Center in Philadelphia, and colleagues treated healthy people as inpatients in a controlled setting with olanzapine, , or placebo for nine days (10 people per group) while maintaining activity levels.

The researchers found that, compared with placebo, olanzapine (which has been strongly associated with weight gain) treatment was associated with significant increases in postprandial insulin, glucagon-like peptide 1, and glucagon, as well as insulin resistance. In contrast, aripiprazole (which has been considered metabolically sparing) had no effect on postprandial hormones but also induced . The changes occurred without weight gain, increase in food intake and hunger, or psychiatric disease.

"Our findings suggest that interventions inhibiting weight gain in atypical antipsychotic-treated patients may be only partially effective in preventing metabolic disease since the drugs are exerting direct effects on tissue function," Teff and colleagues conclude.

Explore further: The metabolic effects of antipsychotic drugs

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DanielHaszard
not rated yet Jul 19, 2013
Remember the Zyprexa scandal.

Zyprexa (Olanzapine) Diabetes connection conflict of interest.
Eli Lilly made $70 billion to date,paid $1.4 billion in criminal fines.
Thousands got diabetes as Zyprexa side effect and have to take Lilly insulin to treat the diabetes that was caused by their Zyprexa.
Eli Lilly Zyprexa can ruin your Pancreas and make you a type 2 diabetic in just a few months of use.I took it 1996-2000 and now am a diabetic for it.

The Eli Lilly company made an astounding $70 BILLION on Zyprexa that they PUSHED on the elderly and underage children (*Viva Zyprexa* Lilly sales rep slogan) with wanton disregard for the side effects
*FIVE at FIVE*
The Zyprexa antipsychotic drug,whose side effects can include weight gain and diabetes, was sold to Veterans,children in foster care, elderly in nursing homes.
*Five at Five* was the Zyprexa sales rep slogan, meaning *5mg dispensed at 5pm would keep patients quiet*.
*Tell the truth don't be afraid*-- Daniel Haszard
http://www.zyprexa-victims.com

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