MRI evaluation of carotid plaque could help define CV risk

May 5, 2014
MRI evaluation of carotid plaque could help define CV risk

(HealthDay)—Carotid artery plaque morphology and composition determined by magnetic resonance imaging (MRI) may be useful in predicting cardiovascular events, according to research published in the May issue of Radiology.

Anna E.H. Zavodni, M.D., of the University of Toronto, and colleagues used MRI to evaluate carotid plaque morphology and composition and ultrasound (US) to measure carotid wall thickness in 946 participants of the Multi-Ethnic Study of Atherosclerosis. The authors assessed the use of these vascular imaging findings to predict cardiovascular events in asymptomatic subjects.

The researchers found that US measurement of carotid intima-media thickness (IMT) and MRI measurements of remodeling index, lipid core, and calcium in the internal were significant predictors of cardiovascular events according to univariate analysis (P < 0.001 for all). For traditional , the C statistic for event prediction was 0.696. For MRI measurements of remodeling index and lipid core, the C statistic was 0.734, and the net reclassification improvement (NRI) was 7.4 percent for participants with cardiovascular events and 15.8 percent for those without (P = 0.02). For US measurements of IMT, the NRI in addition to traditional risk factors was not significant.

"The identification of vulnerable plaque characteristics with aids in cardiovascular disease prediction and improves the reclassification of baseline cardiovascular risk," the authors write.

Explore further: High-risk carotid artery plaque formation is increased in older COPD patients

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Artificial heart design features porous plastic foam

October 2, 2015

Artificial hearts with multiple moving parts increase the chance of failure; scientists have worked up a device which is a single piece. No less interesting is the material they used; the team is taking a page out of soft ...

What powers the pumping heart?

September 25, 2015

Researchers at the Ted Rogers Centre for Heart Research have uncovered a treasure trove of proteins, which hold answers about how our heart pumps—a phenomenon known as contractility.

Sticky gel helps stem cells heal rat hearts

September 24, 2015

A sticky, protein-rich gel created by Johns Hopkins researchers appears to help stem cells stay on or in rat hearts and restore their metabolism after transplantation, improving cardiac function after simulated heart attacks, ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.