Acupuncture with electrical stimulation may treat muscle atrophy caused by kidney disease

August 14, 2014

Acupuncture may help treat muscle wasting that can occur as a result of kidney and other diseases, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The technique may be an attractive non-drug strategy that could help many patients.

Muscle atrophy is a serious consequence of spinal cord injuries and other traumas as well as diseases such as heart failure, (CKD), cancer, and diabetes. While there are several drug-related strategies to help prevent or treat muscle atrophy, there are no simple and effective treatments.

Xiaonan Wang, MD, Li Hu, MD (Emory University), and their colleagues looked to see if electrical stimulation delivered through acupuncture, which any physician can learn to perform with as little as 3 months of training, might lessen muscle atrophy associated with CKD. The investigators treated CKD mice and healthy control mice with the technique, which mimics resistance exercise by inducing , for 15 days.

The researchers found that the treatment improved in mice by activating M2 macrophages, which are specialized immune cells that stimulate an anti-inflammatory response. Activation of M2 macrophages stimulates the insulin-like growth factor-1 signaling pathway, which promotes increased and new muscle cell growth. "Our study explains how acupuncture is able to produce positive effects against muscle atrophy," said Dr. Wang. "Patients with severe disease are frequently unable to withstand routine daily physical activity, let alone therapeutic exercise. This treatment is an alternate way to achieve the benefits of exercise," she added.

The researchers noted that more work is needed to determine the optimal timing and intensity of LFES as a possible treatment for .

Explore further: Japanese researchers show that acupuncture can improve skeletal muscle atrophy

More information: The article, entitled Low-Frequency Electrical Stimulation Attenuates Muscle Atrophy in CKD—A Potential Treatment Strategy," will appear online at on August 14, 2014.

Related Stories

New possible target to combat muscle wasting

April 9, 2014

The pathological atrophy of skeletal muscle is a serious biomedical problem for which no effective treatment is currently available. The most affected populations are the elderly diagnosed with sarcopenia and patients with ...

Recommended for you

Ebola virus mutations may help it evade drug treatment

September 11, 2015

Genetic mutations called "escape variants" in the deadly Ebola virus appear to block the ability of antibody-based treatments to ward off infection, according to a team of U.S. Army scientists and collaborators. Their findings, ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.