The Journal of Clinical Investigation is a monthly open access biomedical scientific journal, with a 2010 impact factor of 14.152. It was established in 1924. The editorial board is unusual in that its members are located chiefly at a single academic medical center and are predominantly members of the American Society for Clinical Investigation. Its leadership changes every five years: As of March 2007, it is located at the University of Pennsylvania and the current editor-in-chief is Laurence A. Turka (Harvard University). From March 2002 to March 2007, the board was located at Columbia University, with Andrew Marks as editor-in-chief.
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There are almost 40 million people throughout the world living with HIV-1/AIDs. While current antiretroviral therapies are able to reduce the amount of virus in the blood, HIV remains present in a latent state within T cells. ...
Mar 30, 2015
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The development of type 2 diabetes is linked to persistent inflammation as a consequence of metabolic stress. Prolonged exposure to the proinflammatory molecule IL-1β is associated with reduced insulin secretion by pancreatic ...
Apr 7, 2016
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Monoclonal antibodies directed against tumor antigens have proven effective for treating some forms of cancer. Despite the increasing use of monoclonal antibody therapy, it is not clear how these antibodies drive tumor removal.
Jan 16, 2014
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β cells in pancreatic islets are responsible for producing insulin, which is essential to regulate blood glucose homeostasis. In type 1 diabetes, pancreatic β cells are destroyed due to an autoimmune attack, whereas in ...
Mar 17, 2016
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Type 1 diabetes is characterized by death and reduced function of β cells, which produce insulin. The presence of specific autoantibodies can identify individuals at risk of developing type 1 diabetes, and many of these ...
Feb 2, 2015
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Individuals with 2p15p16.1 microdeletion syndrome present with intellectual disability, microcephaly, delayed growth, dysmorphic craniofacial features, and digital abnormalities. The precise genetic region responsible for ...
Mar 17, 2016
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Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease characterized by lung fibrosis and declining lung function. There are currently few effective treatments for IPF, and the median survival following diagnosis ...
Apr 7, 2016
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Millions of people throughout the world are affected by diabetes. In particular, the rise in the incidence of type 2 diabetes is associated with global increases in obesity and changes in diet. There is also a genetic component ...
Sep 2, 2014
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Inflammatory joint diseases such as rheumatoid arthritis are the result of cartilage damage and loss. Chondrocytes are the only cells that are found in cartilage and their death is linked to decreased cartilage health.
Aug 1, 2013
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Patients with diabetes and metabolic syndrome are at increased risk of atherosclerosis and subsequent heart disease. It is not fully understood why atherosclerosis is increased with diabetes, but it has been proposed that ...
May 5, 2016
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