Phase I study of temsirolimus, capecitabine proves safe; positive survival trend seen
A phase I clinical trial examining the safety of combining temsirolimus and capecitabine in advanced malignancies suggests the two agents can be given safely to patients. In addition, the Georgetown Lombardi Comprehensive ...
Cancer
May 16, 2012 |
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Researchers uncover genes at fault for cystic fibrosis-related intestinal obstruction
Researchers at Johns Hopkins have identified a gene that modifies the risk of newborns with cystic fibrosis (CF) developing neonatal intestinal obstruction, a potentially lethal complication of CF. Their findings, which appeared ...
Genetics
Apr 23, 2012 |
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Study reveals insight into how key protein protects against viral infections
Scientists from the University of Utah School of Medicine have discovered that a mouse protein called IFITM3 contributes to the body's defense against some types of viral infections by binding to an enzyme responsible for ...
Immunology
Apr 02, 2012 |
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Hot on the trail of metabolic diseases and resistance to antibiotics
Proteins belonging to the large and important family of ABC transporters have been associated with metabolic diseases and can cause resistance to antibiotics. Biochemists from the University of Zurich and the NCCR Structural ...
Medical research
Mar 28, 2012 |
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New research could provide roadmap for more effective drug discovery for cystic fibrosis
A recent study led by Gergely Lukacs, a professor at McGill University's Faculty of Medicine, Department of Physiology, and published in the January issue of Cell, has shown that restoring normal function to the mutant gene p ...
Medical research
Mar 12, 2012 |
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Perception and preference may have genetic link to obesity
About five years ago, animal studies first revealed the presence of entirely novel types of oral fat sensors or receptors on the tongue. Prior to this time, it was believed that fats were perceived only by flavor and texture ...
Health
Mar 05, 2012 |
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An 'off' switch for pain: Chemists build light-controlled neural inhibitor
Pain? Just turn it off! It may sound like science fiction, but researchers based in Munich, Berkeley and Bordeaux have now succeeded in inhibiting pain-sensitive neurons on demand, in the laboratory. The crucial element in ...
Medical research
Feb 22, 2012 |
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Scientists identify protein that sends 'painful touch' signals
In two landmark papers in the journal Nature this week, scientists at The Scripps Research Institute report that they have identified a class of proteins that detect "painful touch."
Medical research
Feb 19, 2012 |
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New tumor suppressor gene identified
A recent study published in Clinical Cancer Research suggests that the protein hVps37A suppresses tumor growth in ovarian cancer. The work, which was funded by the Austrian Science Fund FWF, shows, for th ...
Cancer
Feb 13, 2012 |
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A step closer to understanding, averting drug resistance
(Medical Xpress) -- The multidrug transporter EmrE functions as an asymmetric antiparallel dimer (molecule with two subunits). Drug (blue) transport from the inside to the outside of the cell membrane is accomplished ...
Medical research
Jan 31, 2012 |
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DGK-alpha helps cancer cells gain traction and mobilize
Metastasizing cancer cells often express integrins that provide better traction. A new study in The Journal of Cell Biology reveals how a lipid-converting enzyme helps the cells mobilize these integrins.
Cancer
Jan 23, 2012 |
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Notre Dame researchers report fundamental malaria discovery
A team of researchers led by Kasturi Haldar and Souvik Bhattacharjee of the University of Notre Dame's Center for Rare and Neglected Diseases has made a fundamental discovery in understanding how malaria parasites cause deadly ...
Medical research
Jan 20, 2012 |
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How immune cells move against invaders
UCSF scientists have discovered the unexpected way in which a key cell of the immune system prepares for battle. The finding, they said, offers insight into the processes that take place within these cells and could lead ...
Immunology
Jan 19, 2012 |
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Some breast cancer spread may be triggered by a protein, study shows
Cancers rarely are deadly unless they evolve the ability to grow beyond the tissues in which they first arise. Normally, cells -- even early-stage tumor cells -- are tethered to scaffolding that helps to restrain ...
Cancer
Jan 17, 2012 |
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Study reveals enzyme function, could help find muscular dystrophy therapies
Researchers at the University of Iowa have worked out the exact function of an enzyme that is critical for normal muscle structure and is involved in several muscular dystrophies. The findings, which were published Jan. 6 ...
Medical research
Jan 09, 2012 |
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