Archive: 23/03/2018

A better understanding of how genetics influences responses to mouth cancer drugs could lead to improved treatment

A single letter DNA mutation is a big determinant of whether patients with advanced oral cancer respond to treatments. Researchers from the National Cancer Centre Singapore (NCCS) and A*STAR who uncovered the mechanisms behind ...

Mar 23, 2018

20 gene variants and transgender identity—what does it mean?

The week started strangely.

Mar 23, 2018

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The gene causing new brain disorder

Newly discovered gene mutations may help explain the cause of a disease that drastically impairs walking and thinking.

Mar 23, 2018

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RNA-based therapeutic inhibits a metabolic pathway in tumor-initiating lung cancer cells

RNA-based therapeutics that prevent a key metabolic enzyme from being expressed in tumor-initiating cells (TIC) hold promise for the treatment of lung cancer, an A*STAR team has shown.

Mar 23, 2018

New strategies to combat opioid addiction

In 2000, a doctor from tiny St. Paul, Virginia, asked the School of Medicine for help with a terrible problem. Art Van Zee, M.D., a physician in a community clinic, reported that opioid abuse was sweeping Appalachian coal ...

Mar 23, 2018

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Stem cell reserves found in the stomach have implications for the genesis of gastric cancer

A team of researchers at A*STAR has found that certain cells in the stomach, called chief cells, become stem cells in response to injury, providing a source of new cells. As well as being significant for understanding how ...

Mar 23, 2018

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How do we lose memory? A STEP at a time, researchers say

In mice, rats, monkeys, and people, aging can take its toll on cognitive function. A new study by researchers at Yale and Université de Montréal reveal there is a common denominator to the decline in all of these species—an ...

Mar 23, 2018

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Study probes the role of key protein linked to heart disease, diabetes

Diet-induced diabetes, obesity, and heart disease are leading causes of death worldwide. In their search for novel therapies for these related chronic illnesses, Yale researchers investigated a protein called ANGPTL4. The ...

Mar 23, 2018

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Researchers reveal childhood predictors of becoming overweight or obese

Childhood predictors of becoming overweight or obese as adults in New Zealand include being male, born into a single-parent family, having parents with larger body size, and limited or no breastfeeding, new University of ...

Mar 23, 2018

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Kidney disease imaging

Obstructive nephropathy—a condition in which the flow of urine is blocked—is a primary source of kidney impairment in infants and children.

Mar 23, 2018

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