Lewy body formation in Parkinson's disease: Scientists propose a new molecular roadmap
Proteins form the building blocks of life, but when they form unusual clumps inside the brain, they raise an alarm that something isn't right.
Cell Component: Lewy Bodies
Medical news and research articles
Parkinson's 'trigger' directly observed in human brain tissue for the first time
Scientists have, for the first time, directly visualized and quantified the protein clusters believed to trigger Parkinson's, marking a major advance in the study of the world's fastest-growing neurological disease.
Oct 1, 2025
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Low-oxygen air slows Parkinson's progression and restores movement in mice
Researchers from the Broad Institute and Mass General Brigham have shown that a low-oxygen environment—similar to the thin air found at Mount Everest base camp—can protect the brain and restore movement in mice with Parkinson's-like ...
Aug 6, 2025
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Discovery reveals protein involved in Parkinson's disease also drives skin cancer
A small protein involved in neurodegeneration leading to Parkinson's disease also drives a type of skin cancer known as melanoma, new research led by Oregon Health & Science University finds.
Apr 9, 2025
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Studies of Parkinson's disease have long overlooked Pacific populations—meta-analysis shows why that must change
A form of Parkinson's disease caused by mutations in a gene known as PINK1 has long been labeled rare. But our research shows it's anything but—at least for some populations.
Feb 25, 2025
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Cholesterol metabolism byproduct linked to Parkinson's disease
Researchers led by Zhentao Zhang at Wuhan University, China have discovered a cholesterol metabolite that plays a critical role in the development of Parkinson's disease in mice. Published in the journal PLOS Biology, the ...
Feb 18, 2025
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Protein variant presents a potential new target for developing effective treatments for Parkinson's disease
Researchers at Tel Aviv University (TAU) discovered a new factor in the pathology of Parkinson's disease, which in the future may serve as a target for developing new treatments for this terrible ailment, affecting close ...
Nov 12, 2024
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Scientists use stem cells to recreate a hallmark of Parkinson's disease in human neurons
Lewy bodies are a hallmark of Parkinson's disease (PD) and other related neurological conditions. Understanding why and how they develop is critical to developing better treatments.
Oct 8, 2024
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Antisense oligonucleotide treatment shows promise in treating Parkinson's disease progression
Parkinson's disease (PD), as well as many other neurodegenerative disorders, has shown a link between the abnormal aggregation of a protein called α-synuclein (aSyn) and neuronal death. These aggregates, known as Lewy bodies ...
Jul 25, 2024
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Preclinical model offers new insights into Parkinson's disease process
A new preclinical model offers a unique platform for studying the Parkinson's disease process and suggests a relatively easy method for detecting the disease in people, according to a new study led by Weill Cornell Medicine ...
Jul 23, 2024
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