A new study suggests that people who are at risk for rare genetic forms of frontotemporal dementia should consider being tested for a common gene variant that can protect them against the group of disorders.
May 13, 2025
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Unlike other pathologies, amyotrophic lateral sclerosis (ALS) cannot be reproduced accurately in animal models, complicating the development of effective drugs. Faced with this challenge, a group of researchers from IMDEA ...
May 13, 2025
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Reduced levels of a critical protein are linked to devastating brain diseases like Alzheimer's, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS). Surprisingly, the protein shortage primarily affects the brain's ...
Apr 30, 2025
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Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a study published in Neuron, researchers report 'seeding' this accumulation through fragments of the culprit protein created ...
Mar 28, 2025
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A University of California, Irvine-led research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington's disease and link HD with other neurodegenerative disorders such ...
Jan 8, 2025
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Approximately 5,000 people in the U.S. develop amyotrophic lateral sclerosis (ALS) each year. On average, they survive for only two to five years after being diagnosed, according to the Centers for Disease Control and Prevention.
Nov 8, 2024
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Researchers at the Francis Crick Institute and the UCL Queen Square Institute of Neurology have developed DNA molecules which contain "invisibility cloak" sequences, preventing healthy cells from reading the messages they ...
Oct 4, 2024
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A new type of degenerative brain disease, limbic-predominant age-related TDP-43 encephalopathy (LATE), was recognized just a decade or so ago, and remains relatively unknown.
Aug 13, 2024
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Researchers at Mayo Clinic have established new criteria for a memory-loss syndrome in older adults that specifically impacts the brain's limbic system. It can often be mistaken for Alzheimer's disease. The good news: Limbic-predominant ...
Jul 17, 2024
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In a Canadian discovery powered by philanthropy, a team of Western University researchers led by Dr. Michael Strong has uncovered a potential path toward a cure for amyotrophic lateral sclerosis (ALS).
May 14, 2024
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