In its effort to correlate genomic structure with gene function, the 4D Nucleome Consortium (4DN), led by Job Dekker, Ph.D., at UMass Chan Medical School, has extensively mapped and analyzed the three-dimensional folding ...
Jan 11, 2026
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Standard laboratory tests can fail to detect many disease-causing DNA changes. Now, a novel 3D chromosome mapping method can reliably reveal these hidden structural variants and lead to new discoveries.
Oct 29, 2025
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Northwestern Medicine scientists have discovered how a common virus linked to birth defects and chronic illness manipulates its host's DNA, according to a new study published in Nature Communications.
Aug 28, 2025
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Viruses are entirely dependent on their hosts to reproduce. They ransack living cells for parts and energy and hijack the host's cellular machinery to make new copies of themselves. Herpes simplex virus-1 (HSV-1), it turns ...
Jun 19, 2025
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The genetic makeup and structure of glioblastoma tumors can shift dramatically across different regions of a single tumor, according to a Northwestern Medicine study published in Science Advances.
Jun 2, 2025
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Posterior fossa group A (PFA) ependymoma are rare, treatment-resistant pediatric tumors of the central nervous system that originate in the brain and spinal cord. They have the highest recurrence rate and poorest prognosis ...
Jul 10, 2024
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Researchers at the National Institutes of Health have mapped the 3D organization of genetic material of key developmental stages of human retinal formation, using intricate models of a retina grown in the lab.
Dec 13, 2023
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One of the remaining mysteries of immunology is the exact mechanism that B cells use to generate millions of antibodies with different specificities to protect us from the plethora of pathogens in the environment.
Sep 7, 2023
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In a paper published in NAR Cancer, researchers from the Center for Childhood Cancer Research at Nationwide Children's and their collaborators report a comprehensive 3D chromatin structural analysis and characterization of ...
Jun 14, 2023
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Much of the human genome is made of regulatory regions that control which genes are expressed at a given time within a cell. Those regulatory elements can be located near a target gene or up to 2 million base pairs away from ...
May 8, 2023
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