PAX3 is a transcription factor (proteins involved in converting DNA into RNA) that drives melanoma progression by promoting cell growth, migration and survival, while inhibiting cellular terminal differentiation, which is ...
May 19, 2025
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Research from The University of Western Australia has advanced the development of cancer treatments that enable immune cells to fight tumors more effectively.
May 15, 2025
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Melanoma is one of the most aggressive forms of skin cancer, arising from pigment-producing cells called melanocytes. While early-stage melanoma can often be treated successfully, advanced disease remains difficult to manage. ...
May 9, 2025
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In a preclinical study, Cedars-Sinai investigators have demonstrated how age-related changes to cells surrounding a tumor make melanoma, a deadly skin cancer, more likely to spread in patients aged 70 and older. Their study, ...
May 5, 2025
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Despite decades of public health messaging, Canadians are spending more time in the sun and using less sun protection—raising alarms among researchers as melanoma cases continue to climb.
May 2, 2025
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Scientists at the Icahn School of Medicine at Mount Sinai have discovered a possible reason why some cases of melanoma—a dangerous form of skin cancer—spread to the brain. Their study, published in Molecular Cell, highlights ...
Apr 30, 2025
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A new study from researchers at Moffitt Cancer Center shows that blocking a chemical process called nitrosylation could make one of the most aggressive forms of melanoma more treatable.
Apr 28, 2025
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A new study led by the University of Oxford has revealed that a common and usually harmless virus may positively influence how skin cancer patients respond to current treatments.
Apr 23, 2025
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Monitoring blood levels of DNA fragments shed by dying tumor cells may accurately predict skin cancer recurrence, a new study shows.
Apr 15, 2025
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A novel application for a compound called ML233 has shown promising results for inhibiting melanin production, offering potential new strategies for the treatment of pigment-related skin conditions and at least one type of ...
Apr 15, 2025
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Melanoma i/ˌmɛləˈnoʊmə/ (from Greek μέλας - melas, "dark") is a malignant tumor of melanocytes. Melanocytes are cells that produce the dark pigment, melanin, which is responsible for the color of skin. They predominantly occur in skin, but are also found in other parts of the body, including the bowel and the eye (see uveal melanoma). Melanoma can occur in any part of the body that contains melanocytes.
Melanoma is less common than other skin cancers. However, it is much more dangerous and causes the majority (75%) of deaths related to skin cancer. Worldwide, doctors diagnose about 160,000 new cases of melanoma yearly. The diagnosis is more frequent in women than in men and is particularly common among Caucasians living in sunny climates, with high rates of incidence in Australia, New Zealand, North America, Latin America, and northern Europe. According to a WHO report, about 48,000 melanoma related deaths occur worldwide per year.
The treatment includes surgical removal of the tumor, adjuvant treatment, chemo- and immunotherapy, or radiation therapy. The chance of a cure is greatest when the tumor is discovered while it is still small and thin, and can be entirely removed surgically.
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