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Genetics news
Oncology & Cancer
DAPK3 emerges as a new regulator of migration of triple-negative breast cancer cells
Triple-negative breast cancer (TNBC) is the subtype of breast cancer that is the hardest to treat. TNBC patients account for more than 20,000 cases of this condition annually in the U.S. alone. They experience worse outcomes ...
8 hours ago
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Oncology & Cancer
New technique that makes competition between tumor cells visible can help personalize treatments for multiple myeloma
Not all cells within the same cancer are the same. They all have genetic errors that turn them into tumor cells, but these errors are not identical. In each cancer, there are populations of cells with different mutations, ...
9 hours ago
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How diabetes risk genes make cells less resilient to stress
The cells in your pancreas, like people, can only handle so much stress before they start to break down. Certain stressors, such as inflammation and high blood sugar, contribute to the development of type 2 diabetes by overwhelming ...
13 hours ago
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Cell line models identify cause of melanoma with drug resistance
Melanoma is a type of cancer that originates from melanocytes, the cells responsible for producing skin pigment, and is known as the most lethal form of skin cancer due to its high rates of metastasis and recurrence. With ...
10 hours ago
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Nobel scientist uncovered tiny genetic switches with big potential
Harvard geneticist Gary Ruvkun vividly remembers the late-night phone call with his longtime friend and now 2024 Nobel Prize in Medicine co-laureate Victor Ambros, when they made their groundbreaking discovery of genetic ...
19 hours ago
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How epigenetic modifications can influence the onset and progression of various diseases
Epigenetics, the study of changes in gene function that do not involve alterations to the DNA sequence, plays a pivotal role in understanding the complex interplay between genetics and the environment. A review article titled ...
15 hours ago
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U.S. duo wins Nobel Prize in medicine for discovery of microRNA and gene regulation breakthrough
US scientists Victor Ambros and Gary Ruvkun won the Nobel Prize in Medicine on Monday for their discovery of microRNA and its role in how genes are regulated, solving a decades-old mystery, the Nobel Assembly at Sweden's ...
Oct 7, 2024
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Discovery of key gene offers new hope in treating chronic myeloid leukemia
A key gene that could enhance the treatment success rates of chronic myeloid leukemia (CML) has been discovered by researchers.
Oct 7, 2024
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Study finds common breast cancer treatments may speed aging process
A new study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center has revealed that common breast cancer treatments, including chemotherapy, radiation, and surgery, may accelerate the biological aging ...
Oct 7, 2024
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Scrutinizing cells for clues to a treatment for muscular dystrophy
A research team led by Associate Professor Hidetoshi Sakurai and Researcher Nana Takenaka-Ninagawa recently demonstrated the superior therapeutic potential of iPS cell-derived mesenchymal stromal cells (iMSCs) compared to ...
Oct 7, 2024
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Study reveals key mechanism driving atherosclerosis in Hutchinson-Gilford progeria syndrome
A team of researchers has made a significant breakthrough in understanding the underlying causes of cardiovascular disease in patients with Hutchinson-Gilford progeria syndrome (HGPS), an ultra-rare genetic disorder that ...
Oct 7, 2024
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A histone post-translational modification linked to lifelong susceptibility to stress in mice
Chemical changes to histones, the proteins that help to pack and organize DNA inside cells, play a key role in determining what genes will be consistently activated over the course of an animal or human's life. Past studies ...
PFAS exposure linked to sleep disruptions in young adults
Research led by the Keck School of Medicine of USC has shown that levels of "forever chemicals" in the blood are linked with disruptions to a fundamental pillar of health—sleep.
Oct 4, 2024
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Research points to potential new treatment for aggressive prostate cancer subtype
When researchers at the University of Michigan Rogel Cancer Center first identified a new subtype of aggressive prostate cancer, they knew they needed to understand how this genetic alteration was driving cancer and how to ...
Oct 4, 2024
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Pancreatic cancer tumor map uncovers notable differences between primary and metastatic disease
Indiana University Melvin and Bren Simon Comprehensive Cancer Center researchers have mapped pancreatic cancer tumor ecosystems using tissue from both the primary tumor, which is where cancer first starts to grow in the body, ...
Oct 4, 2024
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Comprehensive mapping of genetic activity brings hope to patients with chronic pain
Researchers at Karolinska Institutet have developed a new comprehensive mapping of genetic activity for understanding the causes of chronic pain. The study, published in Nature Communications, opens the way to more efficient ...
Oct 4, 2024
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Genetic variations in remote UK regions linked to higher disease risk
People from isolated parts of the U.K. could have variations in their genetic code that increase their chance of developing certain diseases, a study suggests.
Oct 4, 2024
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Largest-ever genetic study of epilepsy finds possible therapeutic targets
The largest and most diverse study to date of epilepsy's genetic factors has revealed new potential targets for treatment, both shared by and unique to different subtypes of epilepsy. The findings point to factors involved ...
Oct 3, 2024
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Live-cell model system can decode genetic risk for psychiatric disorders
For many years, scientists have known that genetic variants, or differences in DNA code across people, play some role in neurological and psychiatric disorders. But the details were murky. Now, researchers at the UNC School ...
Oct 3, 2024
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New genomic surveillance tools could help efforts to eliminate damaging parasitic infections
Researchers at Washington University School of Medicine in St. Louis have developed a new genomic-based approach that could aid global efforts to eliminate lymphatic filariasis, a parasitic roundworm infection spread by mosquitos. ...
Oct 3, 2024
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Scientists decode key mutation in many cancers, pointing to expanded role of RNA in human gene expression
Inside every cell, inside every nucleus, your continued existence depends on an incredibly complicated dance. Proteins are constantly wrapping and unwrapping DNA, and even minor missteps can lead to cancer. A new study from ...
Oct 2, 2024
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Researchers develop insights into KRAS mutations in pancreatic cancers
A common mutation in the KRAS gene is associated with improved overall survival in pancreatic ductal adenocarcinoma (PDAC) compared with other variants, in part because the mutation appears to lead to less invasiveness and ...
Oct 2, 2024
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Study reveals molecular mechanism of genetic variant that causes mirror movement disorder
A team of Canadian and American scientists has made a promising breakthrough in understanding the origins of a mysterious neurological disorder known as mirror movements.
Oct 2, 2024
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Scientists uncover genetic cause of rare autoimmune disorder
A team of international scientists has uncovered the genetic underpinnings of a rare, inherited autoimmune disorder, according to a study recently published in Science Translational Medicine.
Oct 2, 2024
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Study reveals key role of TRIO gene in epileptic encephalopathies
What are the molecular and cellular mechanisms by which some babies develop epileptic encephalopathies and autism spectrum disorder? That's what researchers in Canada and France set out to uncover—and they think they've ...
Oct 2, 2024
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