eLife

Medications

Study reveals how diabetes drug extends lifespan in lab models

Metformin, the most commonly used drug to treat type 2 diabetes, not only lowers blood sugar levels but has been revealed to extend lifespan in C. Elegans—an animal model that shares similar metabolic systems with humans ...

Neuroscience

Donor motor neurons could restore muscle function in ALS

Scientists have detailed how a combination of grafted replacement motor neurons and optical nerve stimulation—using light to activate neurons—can improve muscle function in a highly aggressive mouse model of amyotrophic ...

Gastroenterology

Gut contractions influence the composition of the microbiome

Spontaneous rhythmic contractions of the intestinal tract, also known as peristalsis, play an important role in enabling healthy gut function in the vast majority of living organisms. This intrinsic activity appears to be ...

Genetics

Treating anemia with gene scissors

ETH Zurich molecular biologist Mandy Boontanrart is researching gene therapies that could be used to cure two of the most common types of inherited anemia. She has now developed a promising approach for so-called beta-hemoglobinopathies. ...

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