The tumor suppressor p53 does all it can to prevent oncogenes from transforming normal cells into tumor cells by killing defective cells or causing them to become inactive. Sometimes oncogenes manage to initiate tumor development ...
Mar 24, 2014
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The process of producing high-quality, fertile sperm requires many steps. A study in The Journal of Cell Biology shows how the transcription factor p73 promotes this process by regulating the adhesions between developing ...
Mar 24, 2014
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A team of biologists and engineers at the University of California, San Diego has discovered that white blood cells, which repair damaged tissue as part of the body's immune response, move to inflamed sites by walking in ...
Mar 17, 2014
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Adult stem cells and cancer cells have many things in common, including an ability to migrate through tiny gaps in tissue. Both types of cells also experience a trade-off when it comes to this ability; having a flexible nucleus ...
Feb 25, 2014
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Cancer cells have long been known to have higher rates of the energy-generating metabolic pathway known as glycolysis. This enhanced glycolysis, a phenomenon known as the Warburg effect, is thought to allow cancer cells to ...
Feb 24, 2014
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Many proteins at the cell surface are 'decorated' with carbohydrate molecules called glycans. Changes in a cell's glycan profile can greatly alter how it behaves and interacts with its environment, and abnormalities in this ...
Jan 29, 2014
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Kinesins are motor proteins that "walk" along microtubules and transport various cargoes throughout the cell. A study in The Journal of Cell Biology uncovers an unexpected role for one kinesin in the pathway that regulates ...
Jan 27, 2014
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Cancer cells have something that every prisoner longs for—a master key that allows them to escape. A study in The Journal of Cell Biology describes how a protein that promotes tumor growth also enables cancer cells to use ...
Jan 20, 2014
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RNA molecules, used by cells to make proteins, are generally thought to be "silent" when stowed in cytoplasmic granules. But a protein mutated in some ALS patients forms granules that permit translation of stored RNAs, according ...
Dec 2, 2013
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Skin provides a first line of defense against viruses, bacteria and parasites that might otherwise make people ill. When an injury breaks that barrier, a systematic chain of molecular signaling launches to close the wound ...
Nov 15, 2013
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