Journal of General Physiology

Medical research

Unlocking the therapeutic potential of SLC13 transporters

Researchers have provided the first functional analysis of a member of a family of transporter proteins implicated in diabetes, obesity, and lifespan. The study appears in the June issue of The Journal of General Physiology.

Neuroscience

Neurons can use local stores for communication needs

Researchers reveal that neurons can utilize a supremely localized internal store of calcium to initiate the secretion of neuropeptides, one class of signaling molecules through which neurons communicate with each other and ...

Medical research

How cone snail venom minimizes pain

The venom from marine cone snails, used to immobilize prey, contains numerous peptides called conotoxins, some of which can act as painkillers in mammals. A recent study in The Journal of General Physiology provides new insight ...

Medical research

A stable model for an unstable target

A study in The Journal of General Physiology provides new insights about singlet oxygen and sets the stage for better understanding of this highly reactive and challenging substance.

Medical research

Protecting the skin from sun exposure

The ultraviolet radiation (UVR) present in sunlight is the most common environmental carcinogen, and long-term exposure to UVR can lead to skin cancer and premature aging of the skin. To develop better methods of protection ...

Medical research

A trigger for muscular diseases

A University of Arizona doctoral candidate has shown for the first time that genetic mutations in the titin gene can cause skeletal muscle myopathy, a disease in which muscle fibers do not function properly, resulting in ...

Medical research

Nicotine exploits COPI to foster addiction

A study in The Journal of General Physiology helps explain how nicotine exploits the body's cellular machinery to promote addiction. The findings could lead to new therapies to help people quit smoking.

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