Nature Methods

Neuroscience

A new way to watch brain activity in action

It's a neuroscientist's dream: being able to track the millions of interactions among brain cells in animals that move about freely, behaving as they would under natural circumstances. New technology developed at The Rockefeller ...

Oncology & Cancer

Personal cancer vaccines show positive results

Immunotherapies are moving to the forefront of cancer treatment. Recent clinical trials have demonstrated that these approaches can be personalized to the unique mutations profile of each individual's tumor, igniting new ...

Medical research

New methods reveal the biomechanics of blood clotting

Platelets are cells in the blood whose job is to stop bleeding by sticking together to form clots and plug up a wound. Now, for the first time, scientists have measured and mapped the key molecular forces on platelets that ...

Oncology & Cancer

Tapping the genome's social network to find cancer drivers

Any one tumor might harbor mutations in thousands of different genes. The challenge is to find the driver mutations—which fuel cancerous activity, and might be promising treatment targets—within the haystack of passengers ...

Oncology & Cancer

Single-nucleus RNA sequencing, droplet by droplet

Last year Broad researchers described a single-nucleus RNA sequencing method called sNuc-Seq. This system enabled researchers to study the gene expression profiles of difficult-to-isolate cell types as well as cells from ...

Oncology & Cancer

Comparing algorithms that search for cancer mutations

Sanford Burnham Prebys Medical Discovery Institute (SBP) has undertaken the first-ever comparative analysis of a newly emerging category of algorithms that mine genetic information in cancer databases by focusing on internal ...

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