MeSH tree: C12.200.777.419.570.363
New 100-week data from the ongoing Phase I/II study of zigakibart, an investigational anti-APRIL monoclonal antibody, reinforce its potential as a disease-modifying treatment for IgA nephropathy (IgAN). Findings presented ...
Jun 5, 2025
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For patients with active lupus nephritis, obinutuzumab, a humanized type II anti-CD20 monoclonal antibody plus standard therapy is more efficacious for providing a complete renal response than standard therapy alone, according ...
Feb 26, 2025
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IgA nephropathy (IgAN) is an immune response disease affecting the filtering units of the kidneys. It is an intractable disease with a complex physiological process. Streptococcus mutans, a dental caries-causing bacterial ...
Dec 2, 2024
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Chronic kidney disease (CKD) cases and deaths in women surged worldwide between 1990 and 2021, according to a study presented at Kidney Week, the annual meeting of the American Society of Nephrology, held from Oct. 23 to ...
Nov 1, 2024
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The hepatitis E virus affects the liver. But infected liver cells secrete a viral protein that reacts with antibodies in the blood and may form complexes that can damage the filter structure of the kidneys, as researchers ...
Oct 31, 2024
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Atrasentan is associated with a significant and clinically meaningful reduction in proteinuria compared with placebo in patients with immunoglobulin A (IgA) nephropathy, according to a study published online Oct. 25 in the ...
Oct 30, 2024
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A study by researchers at the National Institutes of Health (NIH) and their collaborators has revealed a significant genetic risk factor for kidney disease in people from Ghana and Nigeria. Their study demonstrated that having ...
Oct 28, 2024
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IgA nephropathy is an autoimmune kidney disease, and complement, a component of the innate immune system, plays a role in the condition's pathogenesis. Investigators have developed and tested a novel gene therapy that enters ...
Oct 28, 2024
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IgA nephropathy (IgAN) is an autoimmune kidney disease driven by immune cells that express a protein called CD38 on their surface. A recent Phase II trial revealed that felzartamab, an investigational anti-CD38 monoclonal ...
Oct 25, 2024
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A Berlin-led research team has uncovered critical regulators of severe kidney damage in patients with lupus, an autoimmune disorder affecting an estimated five million people worldwide, most of whom are young women. A small, ...
Aug 14, 2024
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