MeSH tree: C12.950.419.570.363.608
Immunoglobulin A (IgA) nephropathy is an autoimmune disease characterized by the deposition of circulating IgA-containing immune complexes (IgA-ICs) in the glomerular mesangium, leading to mesangial cell proliferation, enhanced ...
Mar 30, 2026
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New research reveals that contrary to conventional belief, primary glomerular diseases are not necessarily benign for children and young adults. In fact, some subsets of children and young adults may experience faster kidney ...
Nov 7, 2025
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New 100-week data from the ongoing Phase I/II study of zigakibart, an investigational anti-APRIL monoclonal antibody, reinforce its potential as a disease-modifying treatment for IgA nephropathy (IgAN). Findings presented ...
Jun 5, 2025
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IgA nephropathy (IgAN) is an immune response disease affecting the filtering units of the kidneys. It is an intractable disease with a complex physiological process. Streptococcus mutans, a dental caries-causing bacterial ...
Dec 2, 2024
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Atrasentan is associated with a significant and clinically meaningful reduction in proteinuria compared with placebo in patients with immunoglobulin A (IgA) nephropathy, according to a study published online Oct. 25 in the ...
Oct 30, 2024
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IgA nephropathy is an autoimmune kidney disease, and complement, a component of the innate immune system, plays a role in the condition's pathogenesis. Investigators have developed and tested a novel gene therapy that enters ...
Oct 28, 2024
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IgA nephropathy (IgAN) is an autoimmune kidney disease driven by immune cells that express a protein called CD38 on their surface. A recent Phase II trial revealed that felzartamab, an investigational anti-CD38 monoclonal ...
Oct 25, 2024
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The annual meeting of the American Society of Nephrology (Kidney Week) was held this year from Nov. 2 to 5 in Philadelphia and attracted participants from around the world, including nephrology specialists, researchers, scientists, ...
Nov 15, 2023
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Swiss pharmaceutical giant Novartis on Monday reported positive interim Phase III results for a new drug being studied to treat a rare kidney disease.
Oct 2, 2023
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Autoimmune diseases are a group of diseases caused by abnormal immune attacks on healthy cells, tissues or organs. Single-cell RNA-sequencing (scRNA-seq) technology provides transcriptomic information at the single-cell resolution, ...
Sep 20, 2023
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