Erosive, but not nonerosive, GERD ups esophageal CA risk

April 26, 2012

(HealthDay) -- Patients with gastroesophageal reflux disease with a history of esophagitis are at increased risk for esophageal adenocarcinoma, although the absolute risk is low, according to a study published in the May issue of Clinical Gastroenterology and Hepatology.

Rune Erichsen, M.D., from Aarhus University in Denmark, and colleagues analyzed data from 33,849 patients with reflux disease (52 percent men; median age, 59.3 years) identified in population-based Danish medical registries from 1996 to 2008. The observed incidence among patients with erosive and nonerosive disease was compared with the expected incidence for the general population.

The researchers found that 77 percent of participants (26,194) had erosive reflux disease, and over a mean follow-up of 7.4 years, 37 subsequently developed esophageal adenocarcinoma. After 10 years, the absolute risk was 0.24 percent. Compared with the expected incidence for the general population, the observed incidence among patients with erosive reflux disease was significantly increased (standardized incidence ratio, 2.2). After 4.5 years of follow-up, only one patient out of 7,655 patients with nonerosive reflux disease was diagnosed with esophageal adenocarcinoma (standardized incidence ratio, 0.3).

"Erosive reflux disease, but not nonerosive disease, increased the risk of esophageal adenocarcinoma, based on analysis of population-based Danish medical registries," the authors write. " therefore might be an important factor in the progression from reflux to esophageal adenocarcinoma."

Explore further: Risk of esophageal cancer in patients with Barrett’s esophagus

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Risk of esophageal cancer in patients with Barrett’s esophagus

October 14, 2011
(Medical Xpress) -- A new study published in the New England Journal of Medicine reveals that the risk of patients with Barrett’s esophagus developing adenocarcinoma of the esophagus are not as high as once originally ...

Smoking found to be a risk factor for Barrett's esophagus

April 11, 2012
(HealthDay) -- Cigarette smoking may be a modifiable risk factor for Barrett's esophagus, according to a study published in the April issue of Gastroenterology.

Recommended for you

Newly-discovered TB blood signal provides early warning for at-risk patients

January 17, 2018
Tuberculosis can be detected in people with HIV infection via a unique blood signal before symptoms appear, according to a new study by researchers from the Crick, Imperial College London and the University of Cape Town.

New study offers insights on genetic indicators of COPD risk

January 16, 2018
Researchers have discovered that genetic variations in the anatomy of the lungs could serve as indicators to help identify people who have low, but stable, lung function early in life, and those who are particularly at risk ...

Previous influenza virus exposures enhance susceptibility in another influenza pandemic

January 16, 2018
While past exposure to influenza A viruses often builds immunity to similar, and sometimes different, strains of the virus, Canadian researchers are calling for more attention to exceptions to that rule.

Don't hold your nose and close your mouth when you sneeze, doctors warn

January 15, 2018
Pinching your nose while clamping your mouth shut to contain a forceful sneeze isn't a good idea, warn doctors in the journal BMJ Case Reports.

New antifungal provides hope in fight against superbugs

January 12, 2018
Microscopic yeast have been wreaking havoc in hospitals around the world—creeping into catheters, ventilator tubes, and IV lines—and causing deadly invasive infection. One culprit species, Candida auris, is resistant ...

Dengue takes low and slow approach to replication

January 11, 2018
A new study reveals how dengue virus manages to reproduce itself in an infected person without triggering the body's normal defenses. Duke researchers report that dengue pulls off this hoax by co-opting a specialized structure ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.