T cells key in atherosclerosis-linked inflammation

August 22, 2012
T cells key in atherosclerosis-linked inflammation
In a mouse model of atherosclerosis, CD4+ T cells interact with antigen-presenting cells in the presence of cognate antigen, leading to cell activation and proliferation and the secretion of proinflammatory cytokines, according to an experimental study published online Aug. 13 in the Journal of Clinical Investigation.

(HealthDay) -- In a mouse model of atherosclerosis, CD4+ T cells interact with antigen-presenting cells (APCs) in the presence of cognate antigen, leading to cell activation and proliferation and the secretion of proinflammatory cytokines, according to an experimental study published online Aug. 13 in the Journal of Clinical Investigation.

Ekaterina K. Koltsova, M.D., Ph.D., of the La Jolla Institute for Allergy and Immunology in California, and colleagues compared the behavior and role of APCs in normal and atherosclerotic mice using live- of explanted aortas.

The researchers found that, in the presence, but not the absence, of cognate antigen, CD4+ T cells were able to interact with fluorescently labeled APCs in the aortic wall. In atherosclerosis-prone mice, APCs interacted with CD4+ T cells in the aorta, which resulted in cell activation and proliferation and the secretion of cytokines (interferon-γ and tumor necrosis factor-α). Uptake of oxidized and minimally modified low-density lipoproteins was enhanced by these cytokines.

"We conclude that antigen presentation by APCs to CD4+ T cells in the arterial wall causes local T-cell activation and production of proinflammatory cytokines, which promote atherosclerosis by maintaining chronic inflammation and inducing foam cell formation," the authors write.

Explore further: A vaccine for heart disease? New discovery points up this possibility

More information: Abstract
Full Text

Related Stories

A vaccine for heart disease? New discovery points up this possibility

August 14, 2012
Most people probably know that heart disease remains the nation's No. 1 killer. But what many may be surprised to learn is that cholesterol has a major accomplice in causing dangerous arterial plaque buildup that can trigger ...

Discovery of immune cells that protect against multiple sclerosis offers hope for new treatment

August 16, 2012
In multiple sclerosis, the immune system attacks nerves in the brain and spinal cord, causing movement problems, muscle weakness and loss of vision. Immune cells called dendritic cells, which were previously thought to contribute ...

How excess alcohol depresses immune function

August 16, 2011
Alcoholism suppresses the immune system, resulting in a high risk of serious, and even life-threatening infections. A new study shows that this effect stems largely from alcohol’s toxicity to immune system cells called ...

New memory for HIV patients

March 26, 2012
The hallmark loss of helper CD4+ T cells during human immunodeficiency virus (HIV) infection may be a red herring for therapeutics, according to a study published on March 26th in the Journal of Experimental Medicine.

Recommended for you

Make way for hemoglobin

August 18, 2017
Every cell in the body, whether skin or muscle or brain, starts out as a generic cell that acquires its unique characteristics after undergoing a process of specialization. Nowhere is this process more dramatic than it is ...

Bio-inspired materials give boost to regenerative medicine

August 18, 2017
What if one day, we could teach our bodies to self-heal like a lizard's tail, and make severe injury or disease no more threatening than a paper cut?

Female mouse embryos actively remove male reproductive systems

August 17, 2017
A protein called COUP-TFII determines whether a mouse embryo develops a male reproductive tract, according to researchers at the National Institutes of Health and their colleagues at Baylor College of Medicine, Houston. The ...

Two-step process leads to cell immortalization and cancer

August 17, 2017
A mutation that helps make cells immortal is critical to the development of a tumor, but new research at the University of California, Berkeley suggests that becoming immortal is a more complicated process than originally ...

Are stem cells the link between bacteria and cancer?

August 17, 2017
Gastric carcinoma is one of the most common causes of cancer-related deaths, primarily because most patients present at an advanced stage of the disease. The main cause of this cancer is the bacterium Helicobacter pylori, ...

New Pathology Atlas maps genes in cancer to accelerate progress in personalized medicine

August 17, 2017
A new Pathology Atlas is launched today with an analysis of all human genes in all major cancers showing the consequence of their corresponding protein levels for overall patient survival. The difference in expression patterns ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.