Outcomes similar with partial, whole breast irradiation

August 24, 2012
Outcomes similar with partial, whole breast irradiation
Accelerated partial breast irradiation yields five-year clinical outcomes and patterns of failure similar to those achieved with whole breast irradiation, with excellent three-year survival for women who develop an ipsilateral breast tumor recurrence, according to a study published in the Sept. 1 issue of Cancer.

(HealthDay)—Accelerated partial breast irradiation (APBI) yields five-year clinical outcomes and patterns of failure similar to those achieved with whole breast irradiation (WBI), with excellent three-year survival for women who develop an ipsilateral breast tumor recurrence (IBTR), according to a study published in the Sept. 1 issue of Cancer.

Chirag Shah, M.D., of the William Beaumont Hospital in Royal Oak, Mich., and colleagues conducted a five-year study involving 1,440 patients with early-stage breast cancer (1,255 with [IBC], 194 with in situ [DCIS]) who underwent breast-conserving therapy (BCT) using ABPI.

The researchers found that 3.5 percent of patients developed an IBTR, for a five-year actuarial rate of 3.61 percent. Of the 50 recurrences, 36 were new primary cancers and 14 were recurrences of the index lesion. The vast majority of recurrences (78 percent) were IBC, and 22 percent were DCIS. After recurrence, 74 percent of women underwent a salvage mastectomy and 26 percent underwent a second BCT procedure. Tamoxifen was given as adjuvant therapy in 16 percent, and 12 percent received systemic chemotherapy. Three years after IBTR, the disease-free survival rate was 58.7 percent, cause-specific survival was 92.1 percent, and overall survival was 80.5 percent.

"In conclusion, with five years of follow-up in a large group of selected patients, APBI produced clinical outcomes and patterns of failure comparable to those reported with WBI," the authors write. "Those patients who developed an IBTR after APBI had excellent three-year survival outcomes after salvage treatment, which, again, was similar to the outcomes of those who developed an IBTR after WBI."

One author disclosed financial ties to Hologic Inc.

Explore further: Older women may not benefit from radiotherapy after breast surgery

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Older women may not benefit from radiotherapy after breast surgery

August 21, 2012
A Rhode Island Hospital radiation oncologist says in a new editorial that research exploring the impact of radiotherapy in older women with low risk of breast cancer recurrence has little effect on actual clinical decisions. ...

APBI associated with more mastectomies, toxicities, complications, compared to traditional radiation

May 1, 2012
Accelerated partial breast irradiation (APBI) brachytherapy, the localized form of radiation therapy growing increasingly popular as a treatment choice for women with early-stage breast cancer, is associated with higher rate ...

Chemotherapy is as effective before breast cancer surgery as after

September 8, 2011
Whether chemotherapy is given before or after breast-conserving therapy (BCT) does not have an impact on long-term local-regional outcomes, suggesting treatment success is due more to biologic factors than chemotherapy timing, ...

Study finds side effects, complications, mastectomy more likely after partial breast irradiation

December 7, 2011
Accelerated partial breast irradiation (APBI) brachytherapy, the localized form of radiation therapy growing increasingly popular as a treatment choice for women with early-stage breast cancer, is associated with higher rate ...

Breast cancer surgery patients benefit from adding radiation therapy

June 4, 2011
Additional radiation treatment improves disease free survival lessening the chance of cancer recurring in women with early breast cancer who have had breast conserving surgery (lumpectomy), interim results of a new study ...

Recommended for you

How cancer metastasis happens: Researchers reveal a key mechanism

January 18, 2018
Cancer metastasis, the migration of cells from a primary tumor to form distant tumors in the body, can be triggered by a chronic leakage of DNA within tumor cells, according to a team led by Weill Cornell Medicine and Memorial ...

Modular gene enhancer promotes leukemia and regulates effectiveness of chemotherapy

January 18, 2018
Every day, billions of new blood cells are generated in the bone marrow. The gene Myc is known to play an important role in this process, and is also known to play a role in cancer. Scientists from the German Cancer Research ...

These foods may up your odds for colon cancer

January 18, 2018
(HealthDay)—Chowing down on red meat, white bread and sugar-laden drinks might increase your long-term risk of colon cancer, a new study suggests.

The pill lowers ovarian cancer risk, even for smokers

January 18, 2018
(HealthDay)—It's known that use of the birth control pill is tied to lower odds for ovarian cancer, but new research shows the benefit extends to smokers or women who are obese.

Researchers develop swallowable test to detect pre-cancerous Barrett's esophagus

January 17, 2018
Investigators at Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center have developed a simple, swallowable test for early detection of Barrett's esophagus that offers promise ...

Scientists zoom in to watch DNA code being read

January 17, 2018
Scientists have unveiled incredible images of how the DNA code is read and interpreted—revealing new detail about one of the fundamental processes of life.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.