Outcomes similar with partial, whole breast irradiation

August 24, 2012
Outcomes similar with partial, whole breast irradiation
Accelerated partial breast irradiation yields five-year clinical outcomes and patterns of failure similar to those achieved with whole breast irradiation, with excellent three-year survival for women who develop an ipsilateral breast tumor recurrence, according to a study published in the Sept. 1 issue of Cancer.

(HealthDay)—Accelerated partial breast irradiation (APBI) yields five-year clinical outcomes and patterns of failure similar to those achieved with whole breast irradiation (WBI), with excellent three-year survival for women who develop an ipsilateral breast tumor recurrence (IBTR), according to a study published in the Sept. 1 issue of Cancer.

Chirag Shah, M.D., of the William Beaumont Hospital in Royal Oak, Mich., and colleagues conducted a five-year study involving 1,440 patients with early-stage breast cancer (1,255 with [IBC], 194 with in situ [DCIS]) who underwent breast-conserving therapy (BCT) using ABPI.

The researchers found that 3.5 percent of patients developed an IBTR, for a five-year actuarial rate of 3.61 percent. Of the 50 recurrences, 36 were new primary cancers and 14 were recurrences of the index lesion. The vast majority of recurrences (78 percent) were IBC, and 22 percent were DCIS. After recurrence, 74 percent of women underwent a salvage mastectomy and 26 percent underwent a second BCT procedure. Tamoxifen was given as adjuvant therapy in 16 percent, and 12 percent received systemic chemotherapy. Three years after IBTR, the disease-free survival rate was 58.7 percent, cause-specific survival was 92.1 percent, and overall survival was 80.5 percent.

"In conclusion, with five years of follow-up in a large group of selected patients, APBI produced clinical outcomes and patterns of failure comparable to those reported with WBI," the authors write. "Those patients who developed an IBTR after APBI had excellent three-year survival outcomes after salvage treatment, which, again, was similar to the outcomes of those who developed an IBTR after WBI."

One author disclosed financial ties to Hologic Inc.

Explore further: Older women may not benefit from radiotherapy after breast surgery

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Where body fat is carried can predict cancer risk

May 23, 2017

Scientists have found that carrying fat around your middle could be as good an indicator of cancer risk as body mass index (BMI), according to research published in the British Journal of Cancer today.

Study offers guidance for targeting residual ovarian tumors

May 23, 2017

Most women diagnosed with ovarian cancer undergo surgery to remove as many of the tumors as possible. However, it is usually impossible to eliminate all of the cancer cells because they have spread throughout the abdomen. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.