Psoriasis patients at high risk of diabetes

August 27, 2012

Patients with psoriasis are at high risk of new-onset diabetes mellitus, according to research presented at ESC Congress 2012. The findings were presented at the press conference by Dr Ole Ahlehoff from Copenhagen University Hospital, Gentofte, Denmark and at the scientific session by Usman KHALID.

Psoriasis is a common that affects approximately 125 million people worldwide. A new study of the entire Danish population confirms previous reports of of diabetes mellitus in with psoriasis and shows that risk increases with severity of psoriasis.

Psoriasis, , and early steps in the development of diabetes mellitus are characterised by , i.e. a chronic state of alert. "This chronic state of alert may explain the increased risk of cardiovascular diseases and diabetes mellitus seen in these patients," said Dr Ahlehoff.

The study comprised more than 4 million people, including approximately 50,000 patients with psoriasis, who were followed for 13 years.

The overall rates of new-onset diabetes mellitus per 1,000 observational years were 3.67 (CI=3.65-3.69) in the reference population who did not have psoriasis, 6.93 (CI=6.63-7.25) for patients with mild psoriasis and 9.65 (CI=8.68-10.73) for patients with severe psoriasis.

The risk of new-onset diabetes mellitus was increased in all patients with psoriasis compared to people who did not have psoriasis. Risk increased with the severity of psoriasis. Compared to people without psoriasis, patients with mild psoriasis were 1.5 times more likely to acquire new-onset diabetes mellitus [rate ratio (RR)=1.49; CI=1.43-1.56] and patients with severe psoriasis were more than twice as likely [RR=2.13; CI=1.91-2.37].

The results remained significant after adjustment for potential confounders, including age, sex, , use of medication, and comorbidity.

Dr Ahlehoff said: "The major conclusion of the study was that psoriasis was associated with increased risk of diabetes mellitus and the risk was highest in patients with severe psoriasis."

"The results add to current evidence of increased risk of cardiovascular and metabolic disease in patients with psoriasis," he added. "More needs to be done to increase awareness in this large group of patients on what steps they can take to decrease their risk factors for cardiovascular disease."

Dr Ahlehoff continued: "Studies are urgently required to examine the impact of aggressive treatment on cardiometabolic outcomes."

Explore further: Psoriasis increases risk of diabetes: study

Related Stories

Psoriasis increases risk of diabetes: study

June 18, 2012
Psoriasis is an independent risk for Type 2 Diabetes, according to a new study by researchers with the Perelman School of Medicine at the University of Pennsylvania, with the greatest risk seen in patients with severe psoriasis. ...

Psoriasis patients face higher than average death risk after a heart attack

September 12, 2011
Heart attack patients with psoriasis are 26 per cent more likely to die from cardiovascular disease, or suffer from recurrent heart attacks or strokes, and are 18 per cent more likely to die from all causes than those without ...

Chronic periodontitis increases risk of psoriasis

July 19, 2012
(HealthDay) -- Patients with chronic periodontitis (CP) are 1.5 times more likely to be diagnosed with psoriasis, and this risk is lessened but not nullified by CP treatment using gingivectomy or periodontal flap operation, ...

Psoriasis patients may face higher heart risk

March 16, 2012
(HealthDay) -- People with the painful skin condition psoriasis may be at increased risk for health problems that affect the heart, an expert says.

Recommended for you

Scientists discover a new way to treat type 2 diabetes

July 21, 2017
Medication currently being used to treat obesity is also proving to have significant health benefits for patients with type 2 diabetes. A new study published today in Molecular Metabolism explains how this therapeutic benefit ...

Alzheimer's drug cuts hallmark inflammation related to metabolic syndrome by 25 percent

July 20, 2017
An existing Alzheimer's medication slashes inflammation and insulin resistance in patients with metabolic syndrome, a potential therapeutic intervention for a highly dangerous condition affecting 30 percent of adults in the ...

Diabetes or its precursor affects 100 million Americans

July 19, 2017
Almost one-third of the US population—100 million people—either has diabetes or its precursor condition, known as pre-diabetes, said a government report Tuesday.

One virus may protect against type 1 diabetes, others may increase risk

July 11, 2017
Doctors can't predict who will develop type 1 diabetes, a chronic autoimmune disease in which the immune system destroys the cells needed to control blood-sugar levels, requiring daily insulin injections and continual monitoring.

Diabetes complications are a risk factor for repeat hospitalizations, study shows

July 7, 2017
For patients with diabetes, one reason for hospitalization and unplanned hospital readmission is severe dysglycemia (uncontrolled hyperglycemia - high blood sugar, or hypoglycemia - low blood sugar), says new research published ...

Researchers identify promising target to protect bone in patients with diabetes

July 7, 2017
Utilizing metabolomics research techniques, NYU Dentistry researchers investigated the underlying biochemical activity and signaling within the bone marrow of hyperglycemic mice with hopes of reducing fracture risks of diabetics

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

Tom_Hennessy
1 / 5 (1) Aug 27, 2012
Could it be the increased iron in the body ?

"Role of free reactive iron in psoriasis"

The government , NIH, is presently conducting a study of Iron Depletion For Type 2 Diabetes and NAFLD.
"Iron Depletion Therapy for Type 2 DM and NAFLD"

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.