Psoriasis patients at high risk of diabetes

August 27, 2012

Patients with psoriasis are at high risk of new-onset diabetes mellitus, according to research presented at ESC Congress 2012. The findings were presented at the press conference by Dr Ole Ahlehoff from Copenhagen University Hospital, Gentofte, Denmark and at the scientific session by Usman KHALID.

Psoriasis is a common that affects approximately 125 million people worldwide. A new study of the entire Danish population confirms previous reports of of diabetes mellitus in with psoriasis and shows that risk increases with severity of psoriasis.

Psoriasis, , and early steps in the development of diabetes mellitus are characterised by , i.e. a chronic state of alert. "This chronic state of alert may explain the increased risk of cardiovascular diseases and diabetes mellitus seen in these patients," said Dr Ahlehoff.

The study comprised more than 4 million people, including approximately 50,000 patients with psoriasis, who were followed for 13 years.

The overall rates of new-onset diabetes mellitus per 1,000 observational years were 3.67 (CI=3.65-3.69) in the reference population who did not have psoriasis, 6.93 (CI=6.63-7.25) for patients with mild psoriasis and 9.65 (CI=8.68-10.73) for patients with severe psoriasis.

The risk of new-onset diabetes mellitus was increased in all patients with psoriasis compared to people who did not have psoriasis. Risk increased with the severity of psoriasis. Compared to people without psoriasis, patients with mild psoriasis were 1.5 times more likely to acquire new-onset diabetes mellitus [rate ratio (RR)=1.49; CI=1.43-1.56] and patients with severe psoriasis were more than twice as likely [RR=2.13; CI=1.91-2.37].

The results remained significant after adjustment for potential confounders, including age, sex, , use of medication, and comorbidity.

Dr Ahlehoff said: "The major conclusion of the study was that psoriasis was associated with increased risk of diabetes mellitus and the risk was highest in patients with severe psoriasis."

"The results add to current evidence of increased risk of cardiovascular and metabolic disease in patients with psoriasis," he added. "More needs to be done to increase awareness in this large group of patients on what steps they can take to decrease their risk factors for cardiovascular disease."

Dr Ahlehoff continued: "Studies are urgently required to examine the impact of aggressive treatment on cardiometabolic outcomes."

Explore further: Psoriasis increases risk of diabetes: study

Related Stories

Psoriasis increases risk of diabetes: study

June 18, 2012

Psoriasis is an independent risk for Type 2 Diabetes, according to a new study by researchers with the Perelman School of Medicine at the University of Pennsylvania, with the greatest risk seen in patients with severe psoriasis. ...

Chronic periodontitis increases risk of psoriasis

July 19, 2012

(HealthDay) -- Patients with chronic periodontitis (CP) are 1.5 times more likely to be diagnosed with psoriasis, and this risk is lessened but not nullified by CP treatment using gingivectomy or periodontal flap operation, ...

Recommended for you

High prevalence of diabetes, prediabetes in China

June 27, 2017

A large, nationally representative survey in 2013 of adults in China finds that the estimated overall prevalence of diabetes was about 11 percent and that of prediabetes was nearly 36 percent, according to a study published ...

Many diabetes patients produce some insulin

June 22, 2017

Some insulin is still produced in almost half of patients that have had type 1 diabetes for more than ten years. The study conducted by researchers at Uppsala University in Sweden has now been published online by the medical ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

Tom_Hennessy
1 / 5 (1) Aug 27, 2012
Could it be the increased iron in the body ?

"Role of free reactive iron in psoriasis"

The government , NIH, is presently conducting a study of Iron Depletion For Type 2 Diabetes and NAFLD.
"Iron Depletion Therapy for Type 2 DM and NAFLD"

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.