Discovery may lead to new drugs to curb obesity, type 2 diabetes

October 11, 2012

(Medical Xpress)—An international study led by a researcher from The University of Western Australia for the Western Australian Institute for Medical Research (WAIMR) has produced exciting results that may lead to new drugs to treat obesity and reduce the incidence of Type 2 diabetes.

UWA Assistant Professor Vance Matthews led researchers in Melbourne, Texas and Japan to explore the effects of a protein on the surface of on conditions such as Type 2 diabetes and obesity.

Their results have appeared in the high-ranking immunology journal Immunology and Cell Biology, published by the .

Assistant Professor Matthews said the research was particularly important because had increased by 75% in the past 25 years, including an alarming increase in overweight and obese children. Insulin resistance correlated directly with obesity and could result in Type 2 diabetes, in which occurred in metabolically active body tissues.

"While my research looks at the growing problems of obesity and type 2 diabetes and how the inflammatory pathways are activated in our bodies, our discoveries also have far-reaching consequences for other diseases that involve inflammation," Assistant Professor Matthews said.

The study established that many parameters of the metabolic syndrome such as obesity and insulin resistance were significantly correlated with high levels of the metalloproteinase known as ADAM28 in .

The group explored interactions between the protein TNF-alpha – which is produced by numerous inflammatory cell types – and the metalloproteinase ADAM28. TNF-alpha is a well-known cytokine that promotes and increases the risk of Type 2 diabetes.

The study highlighted that the metalloproteinase ADAM28 may increase the release of TNF-alpha protein from the cell surface, and this effect may promote inflammation.

"Our project is very significant because it demonstrates for the first time the importance of ADAM28 in the metabolic syndrome, and further supports that metalloproteinase inhibition is a potential therapeutic target for anti-obesity agents," Assistant Professor Matthews said.

"This means that further down the track, drugs may become available to treat obesity, therefore reducing the incidence of type 2 diabetes."

Explore further: Researchers identify key regulator of inflammatory response

Related Stories

Researchers identify key regulator of inflammatory response

April 12, 2012
(Medical Xpress) -- Researchers at Boston University School of Medicine (BUSM) have identified a gene that plays a key role in regulating inflammatory response and homeostasis. These findings could help lead to the development ...

New inflammation hormone link may pave way to study new drugs for Type 2 diabetes

May 15, 2012
A new link between obesity and type 2 diabetes found in mice could open the door to exploring new potential drug treatments for diabetes, University of Michigan Health System research has found.

New tactic for controlling blood sugar in diabetes contradicts current view of the disease

September 4, 2011
Increased low-grade inflammation in the body resulting from obesity is widely viewed as contributing to type 2 diabetes. Going against this long-held belief, researchers from Children's Hospital Boston report that two proteins ...

Recommended for you

Exposure to larger air particles linked to increased risk of asthma in children

December 15, 2017
Researchers at The Johns Hopkins University report statistical evidence that children exposed to airborne coarse particulate matter—a mix of dust, sand and non-exhaust tailpipe emissions, such as tire rubber—are more ...

Bioengineers imagine the future of vaccines and immunotherapy

December 14, 2017
In the not-too-distant future, nanoparticles delivered to a cancer patient's immune cells might teach the cells to destroy tumors. A flu vaccine might look and feel like applying a small, round Band-Aid to your skin.

Immune cells turn back time to achieve memory

December 13, 2017
Memory T cells earn their name by embodying the memory of the immune system - they help the body remember what infections or vaccines someone has been exposed to. But to become memory T cells, the cells go backwards in time, ...

Steroid study sheds light on long term side effects of medicines

December 13, 2017
Fresh insights into key hormones found in commonly prescribed medicines have been discovered, providing further understanding of the medicines' side effects.

The immune cells that help tumors instead of destroying them

December 12, 2017
Lung cancer is the leading cause of cancer-associated deaths. One of the most promising ways to treat it is by immunotherapy, a strategy that turns the patient's immune system against the tumor. In the past twenty years, ...

Cancer gene plays key role in cystic fibrosis lung infections

December 12, 2017
PTEN is best known as a tumor suppressor, a type of protein that protects cells from growing uncontrollably and becoming cancerous. But according to a new study from Columbia University Medical Center (CUMC), PTEN has a second, ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.