Increased risk of carotid artery wall thickening in COPD

November 12, 2012
Increased risk of carotid artery wall thickening in COPD
For older adults with chronic obstructive pulmonary disease, the likelihood of carotid artery thickening is increased and vulnerable lipid core plaques are more frequent than in controls with normal lung function, according to a study published online Nov. 9 in the American Journal of Respiratory and Critical Care Medicine.

(HealthDay)—For older adults with chronic obstructive pulmonary disease (COPD), the likelihood of carotid artery thickening is increased and vulnerable lipid core plaques are more frequent than in controls with normal lung function, according to a study published online Nov. 9 in the American Journal of Respiratory and Critical Care Medicine.

Lies Lahousse, Ph.D., M.P.H., from Ghent University in Belgium, and colleagues investigated the prevalence of carotid wall thickening, the different components of carotid artery plaque, and their associations with severity of airflow limitation in a cross-sectional study involving 253 patients with COPD and 920 controls from the Rotterdam Study (age 55 years and older).

The researchers found that, compared with controls with normal lung function, COPD cases had a significantly increased risk of presentation with carotid artery wall thickening on ultrasonography (odds ratio, 2.0). This risk increased significantly with airflow limitation severity. On , in COPD cases, vulnerable lipid core plaques were significantly more frequent than in controls (odds ratio, 2.1).

"In conclusion, this study shows an increased risk of carotid artery plaque formation and of presence of vulnerable plaques with a lipid core in population-based elderly patients with COPD," the authors write. "Clinicians should be aware that asymptomatic carotid atherosclerosis is more prevalent in subjects with COPD and that COPD as a systemic inflammatory disease might lead to vulnerable plaques by inducing or aggravating the presence of a lipid core."

Explore further: High-risk carotid artery plaque formation is increased in older COPD patients

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

High-risk carotid artery plaque formation is increased in older COPD patients

October 26, 2012
Older patients with chronic obstructive pulmonary disease (COPD) are at increased risk for carotid artery plaque formation and for the presence of vulnerable plaques with a lipid core, according to a new study from researchers ...

Pulmonary artery enlargement predicts exacerbation in COPD

September 4, 2012
(HealthDay)—For patients with chronic obstructive pulmonary disease (COPD), computed tomographic (CT) measurement of pulmonary artery enlargement, as determined by a ratio of the diameter of the pulmonary artery to the ...

Fibrosis and fatty liver disease increase risk of early atherosclerosis

April 24, 2012
Italian researchers report that severe fibrosis increases the early atherosclerosis risk in patients with genotype 1 chronic hepatitis C virus (HCV) infection. A second study found that fatty liver disease also increases ...

Study confirms link between rheumatoid arthritis and COPD

May 26, 2011
Patients with rheumatoid arthritis are two times more likely to have concurrent chronic obstructive pulmonary disease (COPD) than healthy controls -- an association which was sustained even when variables such as age, gender, ...

Roflumilast improves lung function after 6 months compared with placebo

October 22, 2012
Roflumilast was associated with significant improvements in lung function in patients with moderate and severe chronic obstructive pulmonary disease (COPD) after 6 months of treatment compared with placebo.

Recommended for you

Study reveals how MRSA infection compromises lymphatic function

January 17, 2018
Infections of the skin or other soft tissues with the hard-to-treat MRSA (methicillin-resistant Staphylococcus aureus) bacteria appear to permanently compromise the lymphatic system, which is crucial to immune system function. ...

Fresh approach to tuberculosis vaccine offers better protection

January 17, 2018
A unique platform that resulted in a promising HIV vaccine has also led to a new, highly effective vaccine against tuberculosis that is moving toward testing in humans.

Newly-discovered TB blood signal provides early warning for at-risk patients

January 17, 2018
Tuberculosis can be detected in people with HIV infection via a unique blood signal before symptoms appear, according to a new study by researchers from the Crick, Imperial College London and the University of Cape Town.

New study offers insights on genetic indicators of COPD risk

January 16, 2018
Researchers have discovered that genetic variations in the anatomy of the lungs could serve as indicators to help identify people who have low, but stable, lung function early in life, and those who are particularly at risk ...

Previous influenza virus exposures enhance susceptibility in another influenza pandemic

January 16, 2018
While past exposure to influenza A viruses often builds immunity to similar, and sometimes different, strains of the virus, Canadian researchers are calling for more attention to exceptions to that rule.

Don't hold your nose and close your mouth when you sneeze, doctors warn

January 15, 2018
Pinching your nose while clamping your mouth shut to contain a forceful sneeze isn't a good idea, warn doctors in the journal BMJ Case Reports.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.