Can new plasma-based biomaterials speed healing of injured tissues?

April 15, 2013, Mary Ann Liebert, Inc
©2013 Mary Ann Liebert, Inc., publishers

Platelet-rich plasma (PRP) derived from blood contains growth factors and other bioactive molecules that promote healing at sites of tissue injury. However, it is difficult to deliver and retain these molecules at a target site, and clinical results have proven to be mixed – until now. A new solid form of bioactive plasma-based biomaterials, known as PBMs, can accelerate tissue healing. Not only are PBMs easier to work with, inexpensive to produce, and safe to use, they are available as off-the-shelf products. All of these promising advantages, and the potential to use PBMs to enhance healing of difficult-to-treat connective tissue injuries affecting cartilage, tendons, and ligaments, contribute to their unique possibilities as described in the article "Biologically Active Blood Plasma-Based Biomaterials as a New Paradigm for Tissue Repair Therapies," by Smith et al. in Disruptive Science and Technology.

Authors Jason Smith and Alan West, Carmell Therapeutics Corp.; Lee Weiss, Robotics Institute, and Phil Campbell, Institute for Complex Engineered Systems, Carnegie Mellon University; and James Burgess, Department of Neurosurgery, Allegheny General Hospital, Pittsburgh, PA, describe initial studies with PBMs in which they were successfully used to stimulate the repair of a bone defect in a mouse. They conclude that "PBM products have the potential to accelerate healing and reduce pain and complications, enabling patients to return to work and their daily lives more quickly." The authors further discuss the development of the PBM technology, its potential applications, advantages over existing treatment options, and the barriers still to be overcome for clinical implementation.

According to study author Alan West, "There has been much recent interest in the concept of using natural regenerative factors to heal wounds – the use of autologous platelet-rich plasma is seeing wide-scale clinical use for treating musculoskeletal and other injuries. Our plasma-based biomaterials move this concept a quantum leap forward, with materials that have the potential to disrupt the industry with a new category of biologics that are inexpensive to produce, safe, and robust in healing both bone and soft tissue injuries."

"There is a significant need for effective, consistent, and cost effective products that can biologically enhance ," says Editor-in-Chief Alan J. Russell, PhD, Highmark Distinguished Professor, Carnegie Mellon University. "By being cost effective and readily available, PBMs can benefit a wide population of patients in healthcare systems. The research Smith and his colleagues have published has the potential to benefit not only the First World Countries, but also could be practical options for developing nations."

Explore further: Researchers work with platelet-rich plasma to heal chronic wounds in veterans

More information: The article is available free on the Disruptive Science and Technology website at http://www.disruptivescience.com.

Related Stories

Researchers work with platelet-rich plasma to heal chronic wounds in veterans

November 10, 2011
(Medical Xpress) -- During the conflicts in Iraq and Afghanistan, blast injuries resulting from improvised explosive devices, or IEDs, and roadsides bombs took countless lives and left thousands of soldiers who managed to ...

Cartilage repair gel gives injuries a sporting chance

March 8, 2012
A cartilage gel being developed by tissue engineers and biochemists at the University of Sydney could bring increased mobility to people living with debilitating sports injuries.

Recommended for you

Best of Last Year—The top Medical Xpress articles of 2017

December 20, 2017
It was a good year for medical research as a team at the German center for Neurodegenerative Diseases, Magdeburg, found that dancing can reverse the signs of aging in the brain. Any exercise helps, the team found, but dancing ...

Pickled in 'cognac', Chopin's heart gives up its secrets

November 26, 2017
The heart of Frederic Chopin, among the world's most cherished musical virtuosos, may finally have given up the cause of his untimely death.

Sugar industry withheld evidence of sucrose's health effects nearly 50 years ago

November 21, 2017
A U.S. sugar industry trade group appears to have pulled the plug on a study that was producing animal evidence linking sucrose to disease nearly 50 years ago, researchers argue in a paper publishing on November 21 in the ...

Female researchers pay more attention to sex and gender in medicine

November 7, 2017
When women participate in a medical research paper, that research is more likely to take into account the differences between the way men and women react to diseases and treatments, according to a new study by Stanford researchers.

Drug therapy from lethal bacteria could reduce kidney transplant rejection

August 3, 2017
An experimental treatment derived from a potentially deadly microorganism may provide lifesaving help for kidney transplant patients, according to an international study led by investigators at Cedars-Sinai.

Exploring the potential of human echolocation

June 25, 2017
People who are visually impaired will often use a cane to feel out their surroundings. With training and practice, people can learn to use the pitch, loudness and timbre of echoes from the cane or other sounds to navigate ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.