Basophils required for the induction of Th2 immunity to haptens and peptide antigens

May 7, 2013, Kyoto University

Researchers from Kyoto University have reported that basophils play a central role in Th2 induction.

This study was published in the Nature Communications on 23rd April, 2013.

The relative contributions of basophils and in Th2 skewing to foreign antigen exposure remains unclear. Here we report the ability of basophils to induce Th2 polarization upon epicutaneous sensitization with different antigens using basophil conditionally depleted Bas TRECK .

Basophils are responsible for Th2 skewing to haptens and peptide antigens but not in vivo. Consistently, basophils cannot take up or process OVA protein sufficiently, but present OVA peptide to T cells for Th2 differentiation via MHC class II. Intriguingly, basophils promote Th2 skewing upon OVA protein exposure in the presence of dendritic cells. Taken together, our results suggest that basophils alone are able to induce Th2 skewing with haptens and peptide antigens but require dendritic cells for the induction of Th2 for protein antigens upon epicutaneous immunization.

Explore further: Unsung heroes of antibody production

More information: Atsushi, O. et al. Basophils are required for the induction of Th2 immunity to haptens and peptide antigens, Nature Communications 4, Article number: 1738, 2013/04/23/online. dx.doi.org/10.1038/ncomms2740

Related Stories

Unsung heroes of antibody production

August 3, 2012
B cells are the body’s antibody factories, standing by to churn out molecules that selectively target foreign threats as a component of the humoral immune response. However, this process also requires T cells to secrete ...

Rewiring DNA circuitry could help treat asthma

July 5, 2012
(Medical Xpress) -- Reprogramming asthma-promoting immune cells in mice diminishes airway damage and inflammation, and could potentially lead to new treatments for people with asthma, researchers have found.

Recommended for you

Researchers devise decoy molecule to block pain where it starts

January 16, 2018
For anyone who has accidentally injured themselves, Dr. Zachary Campbell not only sympathizes, he's developing new ways to blunt pain.

Scientists unleash power of genetic data to identify disease risk

January 16, 2018
Massive banks of genetic information are being harnessed to shed new light on modifiable health risks that underlie common diseases.

Blood-vessel-on-a-chip provides insight into new anti-inflammatory drug candidate

January 15, 2018
One of the most important and fraught processes in the human body is inflammation. Inflammatory responses to injury or disease are crucial for recruiting the immune system to help the body heal, but inflammation can also ...

Molecule produced by fat cells reduces obesity and diabetes in mice

January 15, 2018
UC San Francisco researchers have discovered a new biological pathway in fat cells that could explain why some people with obesity are at high risk for metabolic diseases such as type 2 diabetes. The new findings—demonstrated ...

Obese fat becomes inflamed and scarred, which may make weight loss harder

January 12, 2018
The fat of obese people becomes distressed, scarred and inflamed, which can make weight loss more difficult, research at the University of Exeter has found.

Optimized human peptide found to be an effective antibacterial agent

January 11, 2018
A team of researchers in the Netherlands has developed an effective antibacterial ointment based on an optimized human peptide. In their paper published in the journal Science Translational Medicine, the group describes developing ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.