Study finds genetic risk factor for knee osteoarthritis

May 14, 2013, University of North Carolina at Chapel Hill School of Medicine

(Medical Xpress)—A newly published paper reports that individuals with radiographic knee osteoarthritis (OA) who had a specific pattern of gene variations in the interleukin-1 receptor antagonist gene (IL1RN), which is involved in controlling inflammation, were more likely to progress to severe disease than those without the gene variations.

In addition, higher , often associated with increased risk for developing severe OA, was only predictive for progression of OA in subjects who had the IL1RN gene variations.

The study was done under the direction of Dr. Joanne Jordan, director of the Thurston Arthritis Research Center at the University of North Carolina School of Medicine. "Progression of knee osteoarthritis often leads to severe disability and total knee replacement in many patients. The factors determining progression are poorly understood," said Dr. Jordan, "and the we reported appear to substantially improve our ability to identify which knee OA patients are more likely to progress. Our goal of course is to use such information to improve drug development and medical management for our OA patients."

The study was published online by the journal Osteaoarthritis and Cartilage on April 18, 2013. It evaluated radiographic progression of knee OA using data from UNC's ongoing Johnston County Osteoarthritis Project, a well characterized population in North Carolina. Of 1,153 subjects, 154 had radiographic signs of knee OA initially. If they had the specific pattern of IL1RN gene variations that is found in approximately 40 percent of Caucasians they were more than twice as likely to have radiographic progression of the disease during the 4 to 11 years monitoring period than all other individuals with knee OA.

"This study was a critical validation of the importance of IL-1 genetic variations in that we have seen in other cohorts," said Dr. Kenneth Kornman, of Interleukin Genetics and a co-author of the study. "We hope to start using this genetic information in partnerships to help guide therapeutic development to improve the management of knee OA."

Explore further: BMI, post-exercise knee laxity change tied to OA progression

More information: www.sciencedirect.com/science/ … ii/S1063458413007632

Related Stories

BMI, post-exercise knee laxity change tied to OA progression

August 21, 2012
(HealthDay) -- In patients with osteoarthritis (OA) of the knee, changes in knee joint laxity during stair climbing or other repetitive physical activity and baseline body mass index (BMI) are associated with disease progression, ...

Walking speed is a marker for knee osteoarthritis

March 20, 2012
(HealthDay) -- Slower walking speed may be a marker for identifying those at risk for knee osteoarthritis (OA), according to a study published online March 5 in Arthritis Care & Research.

'Mobility shoes' take a load off for knee osteoarthritis sufferers

April 10, 2013
New research suggests that patients with knee osteoarthritis (OA) who wear flat, flexible footwear (mobility shoes) had significant reduction in knee loading—the force placed upon the joint during daily activities. Results ...

Tibial trabecular bone texture predicts osteoarthritis progression

March 9, 2012
(HealthDay) -- Changes in medial and lateral trabecular bone texture can predict joint space narrowing (JSN) and progression of knee osteoarthritis (OA), according to research published in the March issue of Arthritis & Rheumatism.

Study looks at pain processing abnormalities in knee OA

September 17, 2012
(HealthDay)—For patients with knee osteoarthritis (K-OA), the lack of correlation between clinical pain and radiographic evidence of disease severity may be due to central sensitization, according to a study published online ...

Recommended for you

Study reveals how MRSA infection compromises lymphatic function

January 17, 2018
Infections of the skin or other soft tissues with the hard-to-treat MRSA (methicillin-resistant Staphylococcus aureus) bacteria appear to permanently compromise the lymphatic system, which is crucial to immune system function. ...

Fresh approach to tuberculosis vaccine offers better protection

January 17, 2018
A unique platform that resulted in a promising HIV vaccine has also led to a new, highly effective vaccine against tuberculosis that is moving toward testing in humans.

New study validates clotting risk factors in chronic kidney disease

January 17, 2018
In late 2017, researchers from Boston University School of Medicine (BUSM) discovered and published (Science Translational Medicine, (9) 417, Nov 2017) a potential treatment target to prevent chronic kidney disease (CKD) ...

Newly-discovered TB blood signal provides early warning for at-risk patients

January 17, 2018
Tuberculosis can be detected in people with HIV infection via a unique blood signal before symptoms appear, according to a new study by researchers from the Crick, Imperial College London and the University of Cape Town.

New study offers insights on genetic indicators of COPD risk

January 16, 2018
Researchers have discovered that genetic variations in the anatomy of the lungs could serve as indicators to help identify people who have low, but stable, lung function early in life, and those who are particularly at risk ...

Previous influenza virus exposures enhance susceptibility in another influenza pandemic

January 16, 2018
While past exposure to influenza A viruses often builds immunity to similar, and sometimes different, strains of the virus, Canadian researchers are calling for more attention to exceptions to that rule.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.